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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Development of Nanoscale Approaches for Ovarian Cancer Therapeutics and Diagnostics

Volume 19, Issue 3-4, 2014, pp. 281-315
DOI: 10.1615/CritRevOncog.2014011455
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ABSTRACT

Ovarian cancer is the deadliest of all gynecological cancers and the fifth leading cause of death due to cancer in women. This is largely due to late-stage diagnosis, poor prognosis related to advanced-stage disease, and the high recurrence rate associated with development of chemoresistance. Survival statistics have not improved significantly over the last three decades, highlighting the fact that improved therapeutic strategies and early detection require substantial improvements. Here, we review and highlight nanotechnology-based approaches that seek to address this need. The success of Doxil, a PEGylated liposomal nanoencapsulation of doxorubicin, which was approved by the FDA for use on recurrent ovarian cancer, has paved the way for the current wave of nanoparticle formulations in drug discovery and clinical trials. We discuss and summarize new nanoformulations that are currently moving into clinical trials and highlight novel nanotherapeutic strategies that have shown promising results in preclinical in vivo studies. Further, the potential for nanomaterials in diagnostic imaging techniques and the ability to leverage nanotechnology for early detection of ovarian cancer are also discussed.

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  2. Pronina Irina V., Loginov Vitaly I., Burdennyy Alexey M., Fridman Marina V., Kazubskaya Tatiana P., Dmitriev Alexey A., Braga Eleonora A., Expression and DNA methylation alterations of seven cancer-associated 3p genes and their predicted regulator miRNAs (miR-129-2, miR-9-1) in breast and ovarian cancers, Gene, 576, 1, 2016. Crossref

  3. Ilekis John V., Tsilou Ekaterini, Fisher Susan, Abrahams Vikki M., Soares Michael J., Cross James C., Zamudio Stacy, Illsley Nicholas P., Myatt Leslie, Colvis Christine, Costantine Maged M., Haas David M., Sadovsky Yoel, Weiner Carl, Rytting Erik, Bidwell Gene, Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, American Journal of Obstetrics and Gynecology, 215, 1, 2016. Crossref

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  6. Brandhonneur N., Hatahet T., Amela-Cortes M., Molard Y., Cordier S., Dollo G., Molybdenum cluster loaded PLGA nanoparticles: An innovative theranostic approach for the treatment of ovarian cancer, European Journal of Pharmaceutics and Biopharmaceutics, 125, 2018. Crossref

  7. Loginov Vitaly I., Pronina Irina V., Burdennyy Alexey M., Filippova Elena A., Kazubskaya Tatiana P., Kushlinsky Dmitry N., Utkin Dmitry O., Khodyrev Dmitry S., Kushlinskii Nikolay E., Dmitriev Alexey A., Braga Eleonora A., Novel miRNA genes deregulated by aberrant methylation in ovarian carcinoma are involved in metastasis, Gene, 662, 2018. Crossref

  8. Burns Austin, Self William T., Antioxidant Inorganic Nanoparticles and Their Potential Applications in Biomedicine, in Smart Nanoparticles for Biomedicine, 2018. Crossref

  9. Asare-Werehene Meshach, Shieh Dar-Bin, Song Yong Sang, Tsang Benjamin K., Molecular and Cellular Basis of Chemoresistance in Ovarian Cancer, in The Ovary, 2019. Crossref

  10. Lim Hui Jun, Ledger William, Targeted Therapy in Ovarian Cancer, Women's Health, 12, 3, 2016. Crossref

  11. Rajitha Balney, Malla Rama Rao, Vadde Ramakrishna, Kasa Prameswari, Prasad Ganji Lakshmi Vara, Farran Batoul, Kumari Seema, Pavitra Eluri, Kamal Mohammad Amjad, Raju Ganji Seeta Rama, Peela Sujatha, Nagaraju Ganji Purnachandra, Horizons of nanotechnology applications in female specific cancers, Seminars in Cancer Biology, 69, 2021. Crossref

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  13. Corradetti Bruna, Pisano Simone, Conlan Robert Steven, Ferrari Mauro, Nanotechnology and Immunotherapy in Ovarian Cancer: Tracing New Landscapes, Journal of Pharmacology and Experimental Therapeutics, 370, 3, 2019. Crossref

  14. Chamani Maryam, Maleki Dana Parisa, Chaichian Shahla, Moazzami Bahram, Asemi Zatollah, Chitosan is a potential inhibitor of ovarian cancer: Molecular aspects, IUBMB Life, 72, 4, 2020. Crossref

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  24. Jit Bimal Prasad, Padhan Biswajita, Sharma Ashok, Nanotechnology and Its Potential Implications in Ovary Cancer, in Bio-Nano Interface, 2022. Crossref

  25. Wallat Jaqueline D., Czapar Anna E., Wang Charlie, Wen Amy M., Wek Kristen S., Yu Xin, Steinmetz Nicole F., Pokorski Jonathan K., Optical and Magnetic Resonance Imaging Using Fluorous Colloidal Nanoparticles, Biomacromolecules, 18, 1, 2017. Crossref

  26. Zhang Tian-Mei, TRIAP1 Inhibition Activates the Cytochrome <b><i>c</i></b>/Apaf-1/Caspase-9 Signaling Pathway to Enhance Human Ovarian Cancer Sensitivity to Cisplatin, Chemotherapy, 64, 3, 2019. Crossref

  27. Bhardwaj Boddapati Kalyani, Thankachan Sanu, Magesh Priyanila, Venkatesh Thejaswini, Tsutsumi Rie, Suresh Padmanaban S., Current Update on Nanotechnology-Based Approaches in Ovarian Cancer Therapy, Reproductive Sciences, 2022. Crossref

  28. Halbur Christopher, Choudhury Niharika, Chen Michael, Kim Jun Hyuk, Chung Eun Ji, siRNA-Conjugated Nanoparticles to Treat Ovarian Cancer, SLAS Technology, 24, 2, 2019. Crossref

  29. Duwa Ramesh, Jeong Jee-Heon, Yook Simmyung, Immunotherapeutic strategies for the treatment of ovarian cancer: current status and future direction, Journal of Industrial and Engineering Chemistry, 94, 2021. Crossref

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