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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2019029527
pages 21-26

Holistic Approach to Cell Characteristics and Behavioral Analysis

Hüseyin Aktug
Department of Histology and Embryology, Ege University, Izmir, Turkey
Berrin Ozdil
Department of Histology and Embryology, Ege University, Izmir, Turkey; Department of Histology and Embryology, Süleyman Demirel University, Isparta, Turkey
Duygu Calik Kocatürk
Department of Histology and Embryology, Ege University, Izmir, Turkey
Eda Acikgoz
Department of Histology and Embryology, Ege University, Izmir, Turkey; Department of Histology and Embryology, Yüzüncü Yil University, Van, Turkey

ABSTRACT

Cancer is a group of diseases of our era that affects not only medical status but also lowers the tone of social and emotional well-being. It also has severe impacts on economies. Cancer cells are linked to the somatic cells and stem cells, with their characteristic similarities and differences. Variations in cell-signaling pathways, such as cell death and proliferation balances, kinetic behavior of the cells, and their differentiation potentials, are the featured parameters for therapeutic targeting. The detection of target points should be based not only on the molecular biology methods but also on the physical and topological analyses from the aspect of "geography is fate". In this review, we focus on the importance of the holistic analyses of intracellular and extracellular dynamics and multidisciplinary cooperation.


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