Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Oncogenesis

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2015013800
pages 227-243

Pediatric Rhabdomyosarcoma

Jack F. Shern
Genetics Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland; Pediatric Oncology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland
Marielle E. Yohe
Genetics Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland; Pediatric Oncology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland
Javed Khan
Genetics Branch, Oncogenomics Section, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland; Pediatric Oncology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland

ABSTRACT

Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood, and despite clinical advances, subsets of these patients continue to suffer high levels of morbidity and mortality associated with their disease. Recent genetic and molecular characterization of these tumors using sophisticated genomics techniques, including next-generation sequencing experiments, has revealed multiple areas that can be exploited for new molecularly targeted therapies for this disease.