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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v7.i1-2.60
pages 89-100

Neurotrophin-Trk Receptor Interactions in Neoplasia: A Possible Role in Interstitial and Perineural Invasion in Ductal Pancreatic Cancer

Shiela J. Miknyoczki
Department of Pathology and Laboratory Medicine, Allegheny University of the Health Sciences, Broad and Vine, Mail Stop 435, Philadelphia, PA 19102-1192
Andres J. P. Klein-Szanto
Fox Chase Cancer Center
Bruce A. Ruggeri
Department of Pathology and Laboratory Medicine, Allegheny University of the Health Sciences, Broad and Vine, Mail Stop 435, Philadelphia, PA 19102-1192

ABSTRACT

Autocrine and paracrine influences of growth factors play a critical role in the regulation of the growth, survival, differentiation, and invasion potential of tumor cells. These influences on the neoplastic phenotype are particularly important in those cancers in which tumor-stroma interactions constitute important components of tumor development, as exemplified by prostatic, breast, and pancreatic carcinomas. The neurotrophins and their corresponding Trk and p75NGFK receptor subtypes are families of growth factors and receptors that have received relatively little attention with respect to neoplasia. This review attempts to summarize their biochemical properties, their role in neuronal and non-neuronal systems, and their involvement in the development of a variety of cancers, particularly those in which perineural invasion and/or metastasis to the CNS are a part of the pathophysiological presentation. In this regard, we have focused on our studies of neurotrophin-Trk/p75NGFR expression and interactions in pancreatic ductal carcinoma (PDAC) and their potential role in the perineural invasive phenotype characteristic of this cancer.


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