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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2018027566
pages 347-370

Molecular Responses of Cancers by Natural Products: Modifications of Autophagy Revealed by Literature Analysis

Andy Wai Kan Yeung
Oral and Maxillofacial Radiology, Applied Oral Sciences, Faculty of Dentistry, University of Hong Kong, Hong Kong, China
Amr El-Demerdash
Sorbonne Universités, Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Molécules de Communication et Adaptation des Micro-Organismes, UMR 7245 CNRS/MNHN, France; Organic Chemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura-35516, Egypt
Ioana Berindan-Neagoe
MEDFUTURE Research Center for Advanced Medicine, 400012 Cluj-Napoca, Romania; Research Center for Functional Genomics, Biomedicine, and Translational Medicine, Institute of Doctoral Studies, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania; Department of Experimental Pathology, "Prof. Ion Chiricuta", The Oncology Institute, Cluj-Napoca, Romania
Atanas G. Atanasov
Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Magdalenka, Poland; Department of Pharmacognosy, University of Vienna, Vienna, Austria
Yuh-Shan Ho
Trend Research Centre, Asia University, Wufeng, Taichung County 41354, Taiwan


Although numerous bibliometric studies have examined various aspects of cancer research, the landscape of scientific studies focusing on natural products in cancer research has not been characterized. Using the Web of Science Core Collection online database, we identify and analyze scientific articles on natural products in cancer-related research. English is the language of publication for 99% of articles. In general, annual citation count of an article increases quickly after publication, reaches a plateau in the second year, stays in this plateau for 10 yr, and then begins to fall. The five most contributing journal categories are medicinal chemistry, contributing the most at 1890 articles (24% of 8012 articles); oncology (20%, with 1572 articles); pharmacology and pharmacy (19%, with 1557); biochemistry and molecular biology (15%, with 1225); and plant sciences (11%, with 883 articles). The United States and Spain yield a larger number of articles with high average citations, and China has been increasing since 2009. Apoptosis and cytotoxicity are the two most-frequently used keywords. Effects of natural products on autophagy with a relevance to cancer are mentioned in 69 publications. Our literature analysis reveals a dynamically evolving landscape and an increasing volume of research investigations that are focused on the study of natural products in the context of cancer. Curcumin, flavonoids, and resveratrol are the most-frequently mentioned natural products. Cancer of the breast, prostate, and colon are the most-frequently mentioned cancers.

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