Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2018027408
pages 333-346

Herbal Medicine in the Mitigation of Reactive Oxygen Species, Autophagy, and Cancer: A Review

Anna Marzvanyan
AT Still University School of Osteopathic Medicine, Mesa, AZ
Vicky Chen
Columbia University School of Nursing, New York, NY
Boshi Zhang
Division of Growth and Development, Section of Orthodontics, UCLA School of Dentistry, Los Angeles, CA
Greg Asatrian
Division of Growth and Development, Section of Orthodontics, UCLA School of Dentistry, Los Angeles, CA


Since the discovery of autophagy in the mid-2000s, the interest in autophagy-related processes within the scientific community has been burgeoning. Countless authors have investigated its function in cellular homeostasis, but arguably of higher importance is its role during pathology. Although primarily a catabolic process, in cancer cells autophagy has numerous downstream effects, being observed to be both pro- and anti-apoptotic. One of the primary factors mediating this differential role of autophagy is the accumulation or sequestration of reactive oxygen species (ROS). Until recently, despite its increasing popularity in the Western world, the efficacy of herbal supplements has been largely anecdotal. Herein, we reviewed the ten most commonly studied herbs in cancer research and their impact on ROS regulation, on the activation and inhibition of autophagy, and ultimately on cancer cell death.

Articles with similar content:

Antitumoral Activity of Sorafenib in Hepatocellular Carcinoma: Effects on Cell Survival and Death Pathways, Cell Metabolism Reprogramming, and Nitrosative and Oxidative Stress
Critical Reviews™ in Oncogenesis, Vol.21, 2016, issue 5-6
Francisco J. Padillo, Jordi Muntané, Maria A. Rodriguez-Hernandez, Elena Navarro-Villaran, Raul Gonzalez, Francisco J. Molina-Ruiz
miRNA: A Diagnostic and Therapeutic Tool for Pancreatic Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 3
Muhammad Imran Qadir, Arooj Faheem
Unanswered Questions in Arsenic Toxicology
Journal of Environmental Pathology, Toxicology and Oncology, Vol.20, 2001, issue 4
T. W. Gebel
Eupatilin, a Pharmacologically Active Flavone Derived from Artemisia Plants, Induces Apoptosis in Human Gastric Cancer (AGS) Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 4
Tae Young Oh, Min-Jung Kim, Do-Hee Kim, Hye-Kyung Na, Young-Joon Surh, Chang-Yell Shin
A New Linkage between the Tumor Suppressor RKIP and Autophagy: Targeted Therapeutics
Critical Reviews™ in Oncogenesis, Vol.23, 2018, issue 5-6
Yuhao Wang, Benjamin Bonavida