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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2019031603
pages 133-137

DNA Fingerprint Technology: Its Application in Detecting Pancreatic Cancer

Gayathri Chalikonda
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322
Neha Merchant
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322
Bhaskar V. K. S. Lakkakula
Sickle Cell Institute Chhattisgarh, Raipur, India
Ganji Purnachandra Nagaraju
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322

ABSTRACT

Pancreatic cancer (PC) is one of the most lethal forms of cancers, ranking as the third highest cause of malignancies and fatalities. Approximately 88% of patients diagnosed with PC are older than 55 yr. Due to PC's vague symptoms, patients typically visit their doctor only when they experience symptoms of extreme pain and/or after their bile ducts have blocked. This produces symptoms including darkly colored urine, jaundice, and light-colored stools. At this point in the progression of the disease, the tumor has already metastasized. Early detection of PC is critical and justifies the need for innovative techniques to efficiently aid in this process. Current research involves screening different aspects of the disease, imaging techniques, and evaluating blood, urine, cell, and saliva biomarkers. We propose that forensic DNA fingerprinting can be used to establish the role of genetics in PC, and we describe disease inheritance patterns so that relatives can understand the likelihood of developing this lethal malignancy.

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