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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2019030929
pages 119-132

Cytogenetic, Molecular, and Translational Applications in Pancreatic Ductal Adenocarcinoma: Current Evidence and Future Concepts

Rama Rao Malla
Cancer Biology Lab, Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India
Seema Kumari
Cancer Biology Lab, Department of Biochemistry and Bioinformatics, Institute of Science, GITAM (Deemed to be University), Visakhapatnam, India


Pancreatic cancer or pancreatic ductal carcinoma is one of the most destructive human malignancies; it is frequently diagnosed at advanced and incurable metastatic stages. In contempt of the voluminous research in the recent past, it became resistant to currently existing, clinically approved therapeutic regimens. Recent advances in cytogenetic, molecular, and translational applications for understanding the pathophysiological and molecular mechanisms of this disease have opened up new avenues for novel therapeutic strategies. In this review, we present current literature on the cytogenetic, molecular, and translational applications in pancreatic ductal carcinoma, and we emphasize current evidence and future concepts for the development of novel diagnostic and therapeutic approaches and their clinical implications.


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