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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Immunotherapeutic Approaches to Head and Neck Cancer

Volume 23, Issue 3-4, 2018, pp. 161-171
DOI: 10.1615/CritRevOncog.2018027641
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ABSTRACT

Head and neck squamous cell carcinoma (HNSCC) is an immunosuppressive disease with multiple mechanisms to impair immune-mediated recognition and control of tumor cell proliferation and metastasis. Based on successes experienced with cancer immunotherapy in the treatment of other solid tumors, considerable efforts are underway to develop immunotherapeutics that can enhance the host antitumor response to HNSCC. Promising results in preclinical studies and early clinical trials have been reported, prompting the FDA to approve the use of the immune checkpoint PD-1 receptor antagonist pembrolizumab for the treatment of platinum-refractory recurrent or metastatic HNSCC in 2016. Ongoing clinical trials are investigating the use of various immunotherapies, such as vaccines, adoptive T-cell transfer, and immune modulating antibodies alone or in conjunction with traditional treatment modalities, to achieve more efficacious, more durable, and less toxic treatments. In this article, we provide a basic review of the role of the immune system in developing malignancy, and we discuss some notable mechanisms of immune evasion in HNSCC. We highlight current approaches and published clinical results of immunotherapy in the treatment of HNSCC.

CITED BY
  1. van Caloen Gabrielle, Machiels Jean-Pascal, Potential role of cyclin-dependent kinase 4/6 inhibitors in the treatment of squamous cell carcinoma of the head and neck, Current Opinion in Oncology, 31, 3, 2019. Crossref

  2. Wu Susan Y., Yom Sue S., Deintensification of Treatment for HPV-Associated Cancers of the Oropharynx, in Textbook of Oral Cancer, 2020. Crossref

  3. Nasser Hassan, St. John Maie A., The promise of immunotherapy in the treatment of young adults with oral tongue cancer, Laryngoscope Investigative Otolaryngology, 5, 2, 2020. Crossref

  4. Izreig Said, Hajek Michael, Edwards Heather A., Mehra Saral, Sasaki Clarence, Judson Benjamin L., Rahmati Rahmatullah W., The role of vitamin D in head and neck cancer, Laryngoscope Investigative Otolaryngology, 5, 6, 2020. Crossref

  5. Trevisani Lorenzo Fernandes Moça, Kulcsar Isabelle Fernandes, Leite Ana Kober Nogueira, Kulcsar Marco Aurélio Vamondes, Lima Graziele Aparecida Simões, Dedivitis Rogerio Aparecido, Kowalski Luiz Paulo, Matos Leandro Luongo, Nutritional and immunological parameters as prognostic factors in patients with advanced oral cancer, Brazilian Journal of Otorhinolaryngology, 2021. Crossref

  6. de Medeiros Marcell Costa, Liu Min, Banerjee Rajat, Bellile Emily, D’Silva Nisha J., Rossa Carlos, Galanin mediates tumor-induced immunosuppression in head and neck squamous cell carcinoma, Cellular Oncology, 45, 2, 2022. Crossref

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