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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v11.i1.10
17 pages

Dendritic Cell-Based Vaccines: From Mouse Models to Clinical Cancer Immunotherapy

Marco W. J. Schreurs
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands
Andreas A. O. Eggert
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands
Cornells J. A. Punt
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands
Carl G. Figdor
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands
Gosse J. Adema
Departments of Tumor Immunology and Medical Oncology, University Hospital Nijmegen St. Radboud, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands

ABSTRACT

B and T lymphocytes are the effectors of specific immunity. However, their function is critically dependent on dendritic cells (DC). DC are professional antigen presenting cells that both initiate and modulate the immune response. The recent breakthrough in the generation of DC from their progenitors has stimulated research on DC in both fundamental and clinical immunology. Objective immune response induction has now been reported in clinical studies using DC. In this review we discuss the development and potential of DC-based vaccines to induce antitumor immunity.


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