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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Cell Death Induction in Cancer Therapy − Past, Present, and Future

Volume 21, Issue 3-4, 2016, pp. 253-267
DOI: 10.1615/CritRevOncog.2016016987
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ABSTRACT

The induction of apoptosis, a physiological type of cell death, is currently the primary therapeutic aim of most cancer therapies. As resistance to apoptosis is an early hallmark of developing cancer, the success of this treatment strategy is already potentially compromised at treatment initiation. In this review, we discuss the tumor in Darwinian terms and describe it as a complex, yet highly unstable, ecosystem. Current therapeutic strategies often focus on directly killing the dominant subclone within the population of mutated cancer cells while ignoring the subclonal complexity within the ecosystem tumor, the complexity of the direct tumor/ microenvironment interaction and the contribution of the ecosystem human − that is, the global environment which provides the tumor with both support and challenges. The Darwinian view opens new possible therapeutic interventions, such as the disruption of the microenvironment by targeting nonmutated cells within the tumor or the interaction points of mutant tumor cells with their environment, and it forces us to reevaluate therapeutic endpoints. It is our belief that a central future challenge of apoptosis-inducing therapies will be to understand better under which preconditions which treatment strategy and which therapeutic endpoint will lead to the highest quality and quantity of a patient's life.

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  1. Derbal Youcef, Perspective on the dynamics of cancer, Theoretical Biology and Medical Modelling, 14, 1, 2017. Crossref

  2. Rashmi K.C., Harsha Raj M., Paul Manoj, Girish Kesturu S., Salimath Bharathi P., Aparna H.S., A new pyrrole based small molecule from Tinospora cordifolia induces apoptosis in MDA-MB-231 breast cancer cells via ROS mediated mitochondrial damage and restoration of p53 activity, Chemico-Biological Interactions, 299, 2019. Crossref

  3. Westhoff Mike-Andrew, Marschall Nicolas, Grunert Michael, Karpel-Massler Georg, Burdach Stefan, Debatin Klaus-Michael, Cell death-based treatment of childhood cancer, Cell Death & Disease, 9, 2, 2018. Crossref

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  5. Selvasaravanan Karthika D., Wiederspohn Nicole, Hadzalic Amina, Strobel Hannah, Payer Christel, Schuster Andrea, Karpel-Massler Georg, Siegelin Markus D., Halatsch Marc-Eric, Debatin Klaus-Michael, Westhoff Mike-Andrew, The limitations of targeting MEK signalling in Glioblastoma therapy, Scientific Reports, 10, 1, 2020. Crossref

  6. Raj R Kathiswar, D Ezhilarasan, S Rajeshkumar, β‐Sitosterol‐assisted silver nanoparticles activates Nrf2 and triggers mitochondrial apoptosis via oxidative stress in human hepatocellular cancer cell line, Journal of Biomedical Materials Research Part A, 108, 9, 2020. Crossref

  7. Qian Hao-Ran, Shi Zhao-Qi, Zhu He-Pan, Gu Li-Hu, Wang Xian-Fa, Yang Yi, Interplay between apoptosis and autophagy in colorectal cancer, Oncotarget, 8, 37, 2017. Crossref

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  14. Konig Sophia, Strobel Hannah, Grunert Michael, Lyszkiewicz Marcin, Brühl Oliver, Karpel-Massler Georg, Ziętara Natalia, La Ferla-Brühl Katia, Siegelin Markus D., Debatin Klaus-Michael, Westhoff Mike-Andrew, Unblinding the watchmaker: cancer treatment and drug design in the face of evolutionary pressure, Expert Opinion on Drug Discovery, 2022. Crossref

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