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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Engaging Cell Death Pathways for the Treatment of Rhabdomyosarcoma

Volume 21, Issue 3-4, 2016, pp. 221-239
DOI: 10.1615/CritRevOncog.2016016996
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ABSTRACT

Rhabdomyosarcoma (RMS), a malignant neoplasm of presumed mesenchymal origin, is the most common soft tissue cancer of childhood. Despite aggressive treatment, resistance to current therapies remains a challenge. The success of most cytotoxic chemotherapies requires intact programmed cell death (apoptosis) pathways. Defects in the cellular apoptotic program play a key role in the pathogenesis of RMS and contribute to chemotherapeutic resistance to current treatments. Targeting and engaging apoptotic pathways using small-molecule IAP antagonists, death-inducing ligands, reestablishing pannexin channel expression and activity, immunotherapies, or a combination of these approaches is expected to improve outcomes in RMS patients. There is a clear need to better understand the molecular basis of apoptotic resistance in RMS, which may provide an opportunity to identify the patients most likely to benefit from targeted treatments, and for the discovery of novel therapies.

CITED BY
  1. Xiang Xiao, Langlois Stéphanie, St-Pierre Marie-Eve, Barré Jessica F., Grynspan David, Purgina Bibianna, Cowan Kyle N., Pannexin 1 inhibits rhabdomyosarcoma progression through a mechanism independent of its canonical channel function, Oncogenesis, 7, 11, 2018. Crossref

  2. Xiang Xiao, Langlois Stéphanie, St-Pierre Marie-Eve, Blinder Anna, Charron Philippe, Graber Tyson E., Fowler Stephanie L., Baird Stephen D., Bennett Steffany A. L., Alain Tommy, Cowan Kyle N., Identification of pannexin 1-regulated genes, interactome, and pathways in rhabdomyosarcoma and its tumor inhibitory interaction with AHNAK, Oncogene, 40, 10, 2021. Crossref

  3. Xiang Xiao, Hoang Huy-Dung, Gilchrist Victoria H., Langlois Stéphanie, Alain Tommy, Cowan Kyle N., Quercetin induces pannexin 1 expression via an alternative transcript with a translationally active 5′ leader in rhabdomyosarcoma, Oncogenesis, 11, 1, 2022. Crossref

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