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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v5.i2-3.90
pages 297-311

The Tumor-Promoting Effect of Wounding: A Possible Role for TGF-β-lnduced Stromal Alterations

Michael H. Sieweke
Division of Life Sciences, Cell and Molecular Biology Department, LBL, University of California, Berkeley, CA 94720
Mina J. Bissell
Division of Life Sciences, Cell and Molecular Biology Department, LBL, University of California, Berkeley, CA 94720

ABSTRACT

From clinical, chemical carcinogenesis and transgenic animal studies, it is evident that wounding has a tumor-promoting effect. We discuss the role of TGF-β (with special emphasis on TGF-β 1) in this process and suggest that stromal alterations during wound healing, induced by TGF-β, can be an important determinant of tumor growth. A tumor and a wound both require similar stromal microenvironments. Thus, a chemically initiated or an oncogene-expressing cell could be complemented to grow into a tumor if it finds itself in a hospitable wound-healing stroma.