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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2017020587
pages 471-479

The Roles of Chromatin Remodeling Genes in Pancreatic-Biliary Malignancies

Claudio Luchini
Department of Diagnostics and Public Health, University and Hospital Trust of Verona, 37142 Verona, Italy; ARC-Net Research Center, University and Hospital Trust of Verona, 37142 Verona, Italy
Alessia Nottegar
Department of Surgery, San Bortolo Hospital, 36100 Vicenza, Italy

ABSTRACT

Recent studies have definitively established that chromatin remodeling is a crucial epigenetic mechanism not only in physiological conditions but also in influencing cancer biology. It is a dynamic process in which the chromatin, the functional entity of DNA, can undergo specific modifications by obtaining transcriptional activation or transcriptional silencing. One of the most important recent discoveries in cancer genetics and genomics is that the genes involved in the establishment of chromatin structure, the so called chromatin remodelers, are frequently mutated in different types of human cancer. This review aims to summarize the main novelties related to this topic, describing also the contribution of such genes during oncogenesis. Particularly, we focus on the switch/sucrose non-fermentable complexes and on three of the most important chromatin remodeling genes in biliary and pancreatic cancer: ARID1A, PBRM1, and BAP1.


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