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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Next-Generation Sequencing for Minimal Residual Disease Surveillance in Acute Lymphoblastic Leukemia: An Update

Volume 22, Issue 5-6, 2017, pp. 559-567
DOI: 10.1615/CritRevOncog.2017020588
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ABSTRACT

Monitoring minimal residual disease (MRD) is an important predictor of outcome in acute lymphoblastic leukemia (ALL) and is used in risk stratification, prognosis determination, and therapy guidance. Several laboratory techniques have proven utility for characterizing leukemic cells and following MRD through diagnosis, remission and possible recurrence. Methods for determining MRD are based on the detection of leukemia-specific aberrant immunophenotypes by mulitparameter flow cytometry or the evaluation of leukemia-specific rearranged immunoglobulin or T-cell receptor sequences by quantitative real-time PCR. Next-generation sequencing (NGS) is emerging as a new flexible and sensitive tool to detect MRD, which allows identification of clonal composition and scalable sensitivity depending on sequence coverage. As NGS becomes more accessible and affordable, guidelines should be established for its application to MRD surveillance.

CITED BY
  1. Rastogi Pulkit, Sachdeva Man Updesh Singh, Flow Cytometric Minimal Residual Disease Analysis in Acute Leukemia: Current Status, Indian Journal of Hematology and Blood Transfusion, 36, 1, 2020. Crossref

  2. Kim In-Suk, Minimal residual disease in acute lymphoblastic leukemia: technical aspects and implications for clinical interpretation, BLOOD RESEARCH, 55, S1, 2020. Crossref

  3. Kovach Alexandra E., Raca Gordana, Bhojwani Deepa, Wood Brent L., Next-Generation Sequencing for Measurable Residual Disease Assessment in Acute Leukemia, Advances in Molecular Pathology, 4, 2021. Crossref

  4. Ho Caleb, Rothberg Paul G., Next-Generation Sequencing–Based Antigen-Receptor Gene Clonality Assays, The Journal of Molecular Diagnostics, 23, 9, 2021. Crossref

  5. Diamanti Paraskevi, Cox Charlotte V., Ede Benjamin C., Uger Robert A., Moppett John P., Blair Allison, Targeting pediatric leukemia-propagating cells with anti-CD200 antibody therapy, Blood Advances, 5, 18, 2021. Crossref

  6. Zhang Xiaohui, Precursor Lymphoid Neoplasms, in Practical Oncologic Molecular Pathology, 2021. Crossref

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