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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v6.i1.20
pages 1-34

Hydrogen Ion-Dependent Oncogenesis and Parallel New Avenues to Cancer Prevention and Treatment Using a H+-Mediated Unifying Approach: pH-Related and pH-Unrelated Mechanisms

Salvador Harguindey
Oncology Service, Clinica la Esperanza, Esperanza 2, 01002, Vitoria, Spain
Jose Luis Pedraz
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country (EHU), Vitoria, Spain
Rafael Garcia Canero
3 Experimental Hepatology Laboratory, Department of Experimental Biochemistry, Clinica, Puerta de Hierro, Madrid, Spain
Javier Perez de Diego
3 Experimental Hepatology Laboratory, Department of Experimental Biochemistry, Clinica, Puerta de Hierro, Madrid, Spain
Edward J. Cragoe, Jr.
4 Consultant in Medicinal Chemistry, Nacogdoches, Texas, USA

ABSTRACT

A comprehensive examination of phenomena related to cancer is presented that is based on hydrogen ion dynamics, as viewed from the biological, biochemical, and biophysical perspective. A model is described that considers an array of cancer-associated events from oncogenesis to carcinogenesis from this perspective. The basic ideas are viewed from various aspects, ranging from the cellular level to the clinical situation. The novel types of therapeutic and prophylactic agents that result from applying these concepts are elucidated. Considerable insight into this modern approach is seen from some of the mechanisms that characterize the phenomenon of spontaneous regression of cancer.


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