Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Oncogenesis
SJR: 0.946 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v6.i1.50
pages 57-85

T and Tn Pancarcinoma Markers: Autoantigenic Adhesion Molecules in Pathogenesis, Prebiopsy Carcinoma-Detection, and Long-Term Breast Carcinoma Immunotherapy

Georg F. Springer
Cancer Biology Research Laboratory University of Health Sciences Chicago Medical School North Chicago, IL 60064

ABSTRACT

Physical and chemical nature of the T and Tn pancarcinoma [CA] glycopeptide epitopes [EPs], which are immediate precursors of the blood group MN EPs, and their role in CA pathogenesis and in clinical disease are discussed. T/Tn are immuno-occluded in non-CA diseased and in healthy tissues. Well-differentiated CAs usually express a higher proportion of T than Tn EPs, while Tn predominates in poorly differentiated primary CAs. Measurement of density of T and Tn EP expression on primary breast CA permits disease prognostication. CA-T and -Tn are cell adhesion molecules involved not only in invasion but also in metastasis. Immunological methods readily detect in vivo autoimmune responses to CA-T and -Tn EPs in about 90 % of all CA patients from incipience and throughout. Everyone has preexisting anti-T and anti-Tn antibodies [Abs] induced by the intestinal flora. T/anti-T immunoassays are highly efficient in detection of incipient and clinically overt CAs and, importantly, predicted CA in 77 % of the patients, months to many years before their biopsy/X-ray turned positive; there were no false immune predictions of CA. Since 1974, we use human О MN red cell-derived T/Tn glycoprotein vaccine plus adjuvants successfully in safe, specific, effective, long-term, active immunotherapy against recurrence of advanced breast CA pTNM Stages IV, III, and II.


Articles with similar content:

Recognition of Melanoma-Derived Antigens by CTL: Possible Mechanisms Involved in Down-Regulating Anti-Tumor T-Cell Reactivity
Critical Reviews™ in Immunology, Vol.18, 1998, issue 1-2
Flavio Arienti, Alessandro Borsatti, Paola Squarcina, Chiara Castelli, Filiberto Belli, Ettore Appella, Francesca Rini, Douglas J. Loftus, Francesco M. Marincola, Giorgio Parmiani, Licia Rivoltini, Carsten Geisler
A Putative Association of Interleukin-1β Promoter Polymorphisms and IL-1β Levels in Saudi Diabetic Patients
Critical Reviews™ in Eukaryotic Gene Expression, Vol.28, 2018, issue 4
Shams Tabrez, Ghulam Md. Ashraf, Salwa Hindawi
Autoimmune Hepatitis: Factors Involved in Initiation and Methods of Diagnosis and Treatment
Critical Reviews™ in Immunology, Vol.36, 2016, issue 5
Marilina Tampoia, Franco Dammacco, Gianfranco Lauletta, Fabio Pavone, Sabino Russi, Andrea Marzullo, Domenico Sansonno
The Proteasome and Its Inhibitors in Immune Regulation and Immune Disorders
Critical Reviews™ in Immunology, Vol.26, 2006, issue 6
Alberto Ballestrero, Franco Patrone, Frank Grunebach, Alessio Nencioni, Peter Brossart
Modeling the Viral Dynamics of Influenza A Virus Infection
Critical Reviews™ in Immunology, Vol.30, 2010, issue 3
Ruy M. Ribeiro, Amber M. Smith