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Critical Reviews™ in Oncogenesis
SJR: 0.946 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v8.i2-3.10
pages 111-142

Escape from Host-Antitumor Immunity

Graham Pawelec
Tubingen Aging and Tumour Immunology Group (TATI), Section for Transplantation Immunology, Medizinische, Center for Medical Research, University of Tuebingen, Tuebingen, Germany
Jesper Zeuthen
TATI, Section for Transplantation Immunology, Medizinische Universitatsklinik, Germany, Department of Tumor Cell Biology, Division of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark, and MTC, Karolinska Institute, Stockholm, Sweden
Rolf Kiessling
Department of Oncology-Pathology, Karolinska Institutet, S-17176 Stockholm, Sweden

ABSTRACT

Cancer cells may express proteins recognizable by the individual's immune system as foreign because they are either tumor-specific or not expressed at high levels in normal tissues to which the host is tolerant. There is now much evidence that tumors can be immunogenic, that is, that they frequently express antigens in a form recognizable by the host immune system. This has been shown not only in experimental animals but also for spontaneously occurring human tumors. Tumors therefore may progress by evolving variants that can evade immune responses or by developing other strategies to "escape" the immune response. The purpose of this review is to consider the current status of knowledge concerning these different tumor escape strategies.


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