Published 4 issues per year
ISSN Print: 0893-9675
ISSN Online: 2162-6448
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The Involvement of Bcr in Leukemias with the Philadelphia Chromosome
ABSTRACT
In this review, the role of Bcr sequences within Bcr-Abl and the role of the Bcr protein itself in leukemias with the Philadelphia chromosome are discussed. An overview of the oncogenic effects of Bcr-Abl is presented together with Bcr-Abl's effects on several signal transduction pathways. Bcr sequences within Bcr-Abl are known to have an important function in transducing Bcr-Abl's oncogenic signal, yet the role of the Bcr protein encoded by the normal allele is not known. However, several recent findings suggest that Bcr is a conditional negative regulator of Bcr-Abl. From these findings, my colleagues and I have developed a molecular model of the early stage (benign phase) of chronic myelogenous leukemia in which the Bcr protein antagonizes the oncogenic effects of Bcr-Abl.
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Kardinal Christian, Konkol Birgit, Lin Hui, Eulitz Manfred, Schmidt Enrico K., Estrov Zeev, Talpaz Moshe, Arlinghaus Ralph B., Feller Stephan M., Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes, Blood, 98, 6, 2001. Crossref
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