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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2019032655
pages 307-338

Role of Epstein-Barr Virus in Glioblastoma

Sergio Zavala-Vega
Área de Virología, Laboratorio de Infectología, Hospital Infantil de México Federico Gómez, Ciudad de México, México; Departamento de Neuropatología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, México
Icela Palma-Lara
Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, México; Departamento de Morfología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México, México
Elizabeth Ortega-Soto
Laboratorio de Inmunovirología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México
Cristina Trejo-Solis
Departamento de Neuroinmunología, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Ciudad de México, México
Israel Torres-Ramirez de Arellano
Departamento de Neuropatología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, México
Luis Eduardo Ucharima-Corona
Departamento de Neuropatología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, México; Facultad de Ciencias, Universidad Nacional Autónoma de México
Guadalupe Garcia-Chacón
Área de Virología, Laboratorio de Infectología, Hospital Infantil de México Federico Gómez, Ciudad de México, México
Sara A. Ochoa
Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Ciudad de México, México
Juan Xicohtencatl-Cortes
Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Ciudad de México, México
Ariadna Cruz-Córdova
Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Ciudad de México, México
Victor Manuel Luna-Pineda
Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Ciudad de México, México
Elva Jiménez-Hernández
Unidad Médica de Alta Especialidad, Hematopediatría, Centro Médico Nacional la Raza IMSS
Eugenio Vázquez-Meraz
Banco de Sangre, Hospital las Américas, Ecatepec Estado de México
Juan Manuel Mejía-Aranguré
Coordinación de Investigación en Salud, IMSS, Torre Academia Nacional de Medicina, Ciudad de México, México
Simón Guzmán-Bucio
Área de Virología, Laboratorio de Infectología, Hospital Infantil de México Federico Gómez, Ciudad de México, México
Daniel Rembao-Bojorquez
Departamento de Neuropatología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, México
Concepción Sánchez-Gómez
Laboratorio de Biología del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez
Marcela Salazar-Garcia
Laboratorio de Biología del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez
José Arellano-Galindo
Área de Virología, Laboratorio de Infectología, Hospital Infantil de México Federico Gómez, Ciudad de México, México


Gliomas are the most common and most lethal primary malignant adult brain tumors, and glioblastomas are the most frequent. Several risk factors are involved in their pathogenesis; these include environmental factors as well as host factors. The etiology of most gliomas remains unknown. Epstein-Barr Virus (EBV), a member of the Herpesviridae family, was the first tumoral virus to be described, and several viruses in connection with cancer were discovered thereafter. During the complex interaction between host and EBV, several events take place. In the context of survival, EBV can drive its host cells with subsequent disruption of the cellular machinery, leading to tumorigenesis as the final outcome. Thus, the EBV infection has been associated with different tumors. In this review, we discuss EBV and cancer. We have analyzed previously published papers and have conducted a critical analysis on the role of the viral infection in glioblastoma. Several works have described the presence of the virus, but none have shown a conclusive association. Thus, there is need to continue analyzing the interaction between host and virus to determine whether the viral presence is incidental or has some association with glioblastoma.


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