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Critical Reviews™ in Biomedical Engineering

Published 6 issues per year

ISSN Print: 0278-940X

ISSN Online: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

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Molecular Aspects of Cardiac Differentiation in Embryonic Stem Cells

Volume 37, Issue 4-5, 2009, pp. 283-320
DOI: 10.1615/CritRevBiomedEng.v37.i4-5.10
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ABSTRACT

Embryonic stem cells (ESCs) are culture-adapted pluripotent cells derived from the inner cell mass of the blastocyst-stage embryo. ESCs provide unique opportunities to study the molecular basis of the process of differentiation that gives rise to all the somatic cell types of the body, including cells of the cardiac lineages. Many protocols have been established to obtain cells of the cardiac lineage from ESCs in vitro. More recently, a clearer picture of the regulatory networks governing cardiac differentiation has begun to emerge. Herein, we summarize the current methods to obtain cells of the cardiac lineages from ESCs and present a review of the signaling pathways, transcription factors, and target genes involved in cardiac differentiation.

CITED BY
  1. Pal Rajarshi, Mamidi Murali Krishna, Das Anjan Kumar, Bhonde Ramesh, Comparative analysis of cardiomyocyte differentiation from human embryonic stem cells under 3-D and 2-D culture conditions, Journal of Bioscience and Bioengineering, 115, 2, 2013. Crossref

  2. Vandsburger Moriel H, Radoul Marina, Cohen Batya, Neeman Michal, MRI reporter genes: applications for imaging of cell survival, proliferation, migration and differentiation, NMR in Biomedicine, 26, 7, 2013. Crossref

  3. Wobus Anna M., Löser Peter, Present state and future perspectives of using pluripotent stem cells in toxicology research, Archives of Toxicology, 85, 2, 2011. Crossref

  4. Sancho Ana, Aldazabal Javier, Rainer Alberto, De-Juan-Pardo Elena M., Rational Design of Artificial Cellular Niches for Tissue Engineering, in Tissue Engineering, 31, 2014. Crossref

  5. He Wenjun, Ye Lingling, Li Shichong, Liu Hong, Wang Qiwei, Fu Xiaobing, Han Weidong, Chen Zhaolie, Stirred Suspension Culture Improves Embryoid Body Formation and Cardiogenic Differentiation of Genetically Modified Embryonic Stem Cells, Biological and Pharmaceutical Bulletin, 35, 3, 2012. Crossref

  6. Wei Wen-Jie, Sun Hai-Ying, Ting Kai Yiu, Zhang Li-He, Lee Hon-Cheung, Li Gui-Rong, Yue Jianbo, Inhibition of Cardiomyocytes Differentiation of Mouse Embryonic Stem Cells by CD38/cADPR/Ca2+ Signaling Pathway, Journal of Biological Chemistry, 287, 42, 2012. Crossref

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