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Critical Reviews™ in Biomedical Engineering

Published 6 issues per year

ISSN Print: 0278-940X

ISSN Online: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

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Embryonic and Induced Pluripotent Stem Cells as a Model for Liver Disease

Volume 37, Issue 4-5, 2009, pp. 377-398
DOI: 10.1615/CritRevBiomedEng.v37.i4-5.40
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ABSTRACT

Induced pluripotent stem (iPS) cells are human somatic cells that have been reprogrammed to a pluripotent state. Through several elegant technologies, we are now able to generate human iPS cells with disease genotypes that could serve as invaluable tools for human disease modeling. This could lead to an understanding of the root causes of a disease and to the development of effective prophylactic and therapeutic strategies for it. However, we are still far from generating fully functional liver cells from stem cells, including iPS cells, on in vitro culture systems. Tissue-engineering techniques have opened the window to inducing a functional fate for differentiated cells by providing a microenvironment that allows the maintenance of signals similar to those found in the natural microenvironment. Here we review the current technology to establish iPS cells and discuss strategies to generate human liver disease modeling using iPS cell technology in concert with bioengineering approaches.

CITED BY
  1. Taylor Doris A., Sampaio Luiz C., Stem Cells and Liver Regeneration, in Transplantation of the Liver, 2015. Crossref

  2. Idriss Salam, Zibara Kazem, Cariou Bertrand, Si-Tayeb Karim, From Human-Induced Pluripotent Stem Cells to Liver Disease Modeling: A Focus on Dyslipidemia, Current Pathobiology Reports, 3, 1, 2015. Crossref

  3. Ng Soon Seng, Xiong Anming, Nguyen Khanh, Masek Marilyn, No Da Yoon, Elazar Menashe, Shteyer Eyal, Winters Mark A., Voedisch Amy, Shaw Kate, Rashid Sheikh Tamir, Frank Curtis W., Cho Nam Joon, Glenn Jeffrey S., Long-term culture of human liver tissue with advanced hepatic functions, JCI Insight, 2, 11, 2017. Crossref

  4. Robertson Matthew J., Soibam Benjamin, O’Leary Jacqueline G., Sampaio Luiz C., Taylor Doris A., Zhao Feng, Recellularization of rat liver: An in vitro model for assessing human drug metabolism and liver biology, PLOS ONE, 13, 1, 2018. Crossref

  5. Takagi Chisato, Yagi Hiroshi, Hieda Makiko, Tajima Kazuki, Hibi Taizo, Abe Yuta, Kitago Minoru, Shinoda Masahiro, Itano Osamu, Kitagawa Yuko, Mesenchymal Stem Cells Contribute to Hepatic Maturation of Human Induced Pluripotent Stem Cells, European Surgical Research, 58, 1-2, 2017. Crossref

  6. Yao Jia, Yu Yue, Nyberg Scott L., Induced Pluripotent Stem Cells for the Treatment of Liver Diseases: Novel Concepts, Cells Tissues Organs, 2022. Crossref

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