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Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Print: 0278-940X
ISSN Online: 1943-619X

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v39.i2.10
pages 79-80

State of the Art and Future Challenges in Neural Engineering: Strategies for Nervous System Repair Foreword / Editors' Commentary (Volume 2)

D. Kacy Cullen
Center for Brain Injury and Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; Penn Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA
Bryan J. Pfister
Department of Biomedical Engineering, New Jersey Institute of Technology, USA


This issue of Critical Reviews in Biomedical Engineering is volume two of a three volume series focused on neural engineering. The theme of this volume is "Strategies for Nervous System Repair." These articles present a range of biomedical engineering strategies to improve outcomes with specific focus given to neural tissue engineering and biomaterial strategies for the repair of spinal cord and peripheral nerve injury. These articles emanate from a unique workshop presented at the 2009 Biomedical Engineering Society Annual Meeting in Pittsburgh, PA, titled "Tissue Engineering of the Nervous System: Approaches and Strategies for the Repair of Peripheral and Spinal Cord Injuries." At times, neurobiologists can be wary of tissue engineering due to a misunderstanding of an engineering approach, or due to an engineer's design that disregards aspects of the surrounding biology, neuroanatomy, or the goals of the surgeon. For instance, novel biomaterial scaffolds are frequently proposed; however, the biology beyond the material is not often considered. In other cases, the efficacy of a new tissue-engineering approach is not evaluated against the gold standard clinical treatment or in the best injury model. This workshop brought leading neurobiologists, clinicians, and engineers together to redefine and revitalize the tissue engineering approach to nervous system repair. Presentations from leading experts addressed the state of the art, identified key challenges, and discussed the most promising opportunities for progress. The articles in this volume were formulated from the resulting discussions.

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