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Critical Reviews™ in Biomedical Engineering
SJR: 0.243 SNIP: 0.376 CiteScore™: 0.79

ISSN Print: 0278-940X
ISSN Online: 1943-619X

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v34.i6.30
pages 491-542

Thermal Therapy, Part 2: Hyperthermia Techniques

Riadh W. Y. Habash
McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health/School of Information Technology and Engineering, University of Ottawa, Ottawa, Ontario, Canada
Rajeev Bansal
Department of Electrical and Computer Engineering, University of Connecticut, Connecticut, USA
Daniel Krewski
McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, Ontario, Canada
Hafid T. Alhafid
College of Engineering and Applied Sciences, Al Ghurair University, Dubai, UAE; and McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, Ontario, Canada

ABSTRACT

Hyperthermia, the procedure of raising the temperature of a part of or the whole body above normal for a defined period of time, is applied alone or as an adjunctive with various established cancer treatment modalities such as radiotherapy and chemotherapy. Clinical hyperthermia falls into three broad categories, namely, (1) localized hyperthermia, (2) regional hyperthermia, and (3) whole-body hyperthermia (WBH). Because of the various problems associated with each type of treatment, different heating techniques have evolved. In this article, background information on the biological rationale and current status of technologies concerning heating equipment for the application of hyperthermia to human cancer treatment are provided. The results of combinations of other modalities such as radiotherapy or chemotherapy with hyperthermia as a new treatment strategy are summarized. The article concludes with a discussion of challenges and opportunities for the future.