Published 6 issues per year
ISSN Print: 0278-940X
ISSN Online: 1943-619X
Indexed in
Ultrasound Elastography: Principles, Techniques, and Clinical Applications
ABSTRACT
Ultrasound elastography is an emerging set of imaging modalities used to image tissue elasticity and are often referred to as virtual palpation. These techniques have proven effective in detecting and assessing many different pathologies, because tissue mechanical changes often correlate with tissue pathological changes. This article reviews the principles of ultrasound elastography, many of the ultrasound-based techniques, and popular clinical applications. Originally, elastography was a technique that imaged tissue strain by comparing pre- and postcompression ultrasound images. However, new techniques have been developed that use different excitation methods such as external vibration or acoustic radiation force. Some techniques track transient phenomena such as shear waves to quantitatively measure tissue elasticity. Clinical use of elastography is increasing, with applications including lesion detection and classification, fibrosis staging, treatment monitoring, vascular imaging, and musculoskeletal applications.
-
Schellpfeffer Michael A., Ultrasound imaging in research and clinical medicine, Birth Defects Research Part C: Embryo Today: Reviews, 99, 2, 2013. Crossref
-
DiDomenico Paul, Middleton William, Sonographic Evaluation of Palpable Superficial Masses, Radiologic Clinics of North America, 52, 6, 2014. Crossref
-
Miller D.L., Biological Effects in Diagnostic Ultrasound, in Comprehensive Biomedical Physics, 2014. Crossref
-
Busilacchi A., Olivieri M., Ulisse S., Gesuita R., Skrami E., Lording T., Fusini F., Gigante A., Real-time sonoelastography as novel follow-up method in Achilles tendon surgery, Knee Surgery, Sports Traumatology, Arthroscopy, 24, 7, 2016. Crossref
-
Fu Ying, Shi Yun-Fei, Yan Kun, Wang Yan-Jie, Yang Wei, Feng Guo-Shuang, Clinical Value of Real Time Elastography in Patients with Unexplained Cervical Lymphadenopathy: Quantitative Evaluation, Asian Pacific Journal of Cancer Prevention, 15, 13, 2014. Crossref
-
Salah Elwagdy, Hassan Ismail, Reda Ramadan, Ahmed Algebally, Ahmed Aboul-Fotouh, Gamal A-Hassan, Transrectal elastographic monitoring of the transurethral balloon pressure in urethral dilation for catheter-dependent patients with benign prostatic hyperplasia, The Egyptian Journal of Radiology and Nuclear Medicine, 45, 4, 2014. Crossref
-
Huang Chien-Chung, Lin Chia-Shiang, Ultrasound-guided chronic musculoskeletal pain control, Acta Anaesthesiologica Taiwanica, 52, 3, 2014. Crossref
-
◾ Finite Element Methods and Inverse Solutions for Elasticity Measurement, in Measurement of Soft Tissue Elasticity in Vivo, 2015. Crossref
-
Zhang Shanshan, Zhu Jiaan, Zhang Xia, He Jing, Li Jianguo, Assessment of the Stiffness of Major Salivary Glands in Primary Sjögren's Syndrome through Quantitative Acoustic Radiation Force Impulse Imaging, Ultrasound in Medicine & Biology, 42, 3, 2016. Crossref
-
Dorado Cortez C., Hermitte L., Ramain A., Mesmann C., Lefort T., Pialat J.B., Ultrasound shear wave velocity in skeletal muscle: A reproducibility study, Diagnostic and Interventional Imaging, 97, 1, 2016. Crossref
-
Trifanov Dmitry S., Dhyani Manish, Bledsoe Jacob R., Misdraji Joseph, Bhan Atul K., Chung Raymond T., Samir Anthony E., Amyloidosis of the liver on shear wave elastography: case report and review of literature, Abdominal Imaging, 40, 8, 2015. Crossref
-
Carpenter Elizabeth L., Lau Heather A., Kolodny Edwin H., Adler Ronald S., Skeletal Muscle in Healthy Subjects versus Those withGNE-Related Myopathy: Evaluation with Shear-Wave US—A Pilot Study, Radiology, 277, 2, 2015. Crossref
-
Van Beers Bernard E., Daire Jean-Luc, Garteiser Philippe, New imaging techniques for liver diseases, Journal of Hepatology, 62, 3, 2015. Crossref
-
Deng Cheri X., Hong Xiaowei, Stegemann Jan P., Ultrasound Imaging Techniques for Spatiotemporal Characterization of Composition, Microstructure, and Mechanical Properties in Tissue Engineering, Tissue Engineering Part B: Reviews, 22, 4, 2016. Crossref
-
Lu Rong, Xiao Ying, Liu Minhui, Shi Dazun, Ultrasound Elastography in the Differential Diagnosis of Benign and Malignant Cervical Lesions, Journal of Ultrasound in Medicine, 33, 4, 2014. Crossref
-
Kwok Sheldon J. J., Kuznetsov Ivan A., Kim Moonseok, Choi Myunghwan, Scarcelli Giuliano, Yun Seok Hyun, Selective two-photon collagen crosslinking in situ measured by Brillouin microscopy, Optica, 3, 5, 2016. Crossref
-
Salamonsen Matthew R, Lo Ada K. C, Ng Arnold C. T, Bashirzadeh Farzad, Wang William Y. S, Fielding David I. K, Novel Use of Pleural Ultrasound Can Identify Malignant Entrapped Lung Prior to Effusion Drainage, Chest, 146, 5, 2014. Crossref
-
Siu Wai-lam, Chan Chi-ho, Lam Cheuk-hei, Lee Chu-man, Ying Michael, Sonographic evaluation of the effect of long-term exercise on Achilles tendon stiffness using shear wave elastography, Journal of Science and Medicine in Sport, 19, 11, 2016. Crossref
-
Larocerie-Salgado Juliana, Davidson John S. D., Nonoperative Management of Finger Flexion Contracture in Dupuytren’s Disease: Orthotic Intervention and Tissue Mobilization Techniques, in Dupuytren’s Contracture, 2016. Crossref
-
Júnior J F S Costa, Parcero G C, Machado J C, Comparison analysis of four processing methods employed in dynamic elastography to estimate viscoelastic parameters of a medium: tests using computational simulation and experiment, Biomedical Physics & Engineering Express, 3, 2, 2017. Crossref
-
Hou Stephanie W., Merkle Alexander N., Babb James S., McCabe Robert, Gyftopoulos Soterios, Adler Ronald S., Shear Wave Ultrasound Elastographic Evaluation of the Rotator Cuff Tendon, Journal of Ultrasound in Medicine, 36, 1, 2017. Crossref
-
Pandey Pallavi, Pandey Ankur, Dillhoff Mary, Schmidt Carl, Kamel Ihab R., Pawlik Timothy M., Assessing the Non-tumorous Liver: Implications for Patient Management and Surgical Therapy, Journal of Gastrointestinal Surgery, 22, 2, 2018. Crossref
-
Costa Júnior José Francisco Silva, Machado João Carlos, Ultrasonic method of microvibration detection: part II - additional processing method and applications, Research on Biomedical Engineering, 33, 3, 2017. Crossref
-
Sperandeo Marco, Trovato Francesca M, Dimitri Lucia, Catalano Daniela, Simeone Anna, Martines Giuseppe Fabio, Piscitelli Angela Pamela, Trovato Guglielmo M, Lung transthoracic ultrasound elastography imaging and guided biopsies of subpleural cancer: a preliminary report, Acta Radiologica, 56, 7, 2015. Crossref
-
Turkay Rustu, Inci Ercan, Aydeniz Banu, Vural Meltem, Shear wave elastography findings of de Quervain tenosynovitis, European Journal of Radiology, 95, 2017. Crossref
-
Lei Zhikai, Lou Jun, Bao Lingyun, Lv Zhuying, Contrast-enhanced ultrasound for needle biopsy of central lung cancer with atelectasis, Journal of Medical Ultrasonics, 45, 3, 2018. Crossref
-
Inci Ercan, Turkay Rustu, Nalbant Mustafa Orhan, Yenice Mustafa Gurkan, Tugcu Volkan, The value of shear wave elastography in the quantification of corpus cavernosum penis rigidity and its alteration with age, European Journal of Radiology, 89, 2017. Crossref
-
Pyciński Bartłomiej, Juszczyk Jan, Obuchowicz Rafał, Shear Wave Elastography and Strain Elastography: a Study on a Phantom, in Innovations in Biomedical Engineering, 623, 2018. Crossref
-
Turkay Rustu, Inci Ercan, Bas Derya, Atar Arda, Shear Wave Elastographic Alterations in the Kidney After Extracorporeal Shock Wave Lithotripsy, Journal of Ultrasound in Medicine, 37, 3, 2018. Crossref
-
Zhou Zhuhuang, Wu Weiwei, Wu Shuicai, Xia Jingjing, Wang Chiao-Yin, Yang Chunlan, Lin Chung-Chih, Tsui Po-Hsiang, A survey of ultrasound elastography approaches to percutaneous ablation monitoring, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 228, 10, 2014. Crossref
-
Akkaya Mustafa, Cay Nurdan, Gursoy Safa, Simsek Mehmet Emin, Tahta Mesut, Doğan Metin, Bozkurt Murat, Sonoelastography of the knee joint, Clinical Anatomy, 32, 1, 2019. Crossref
-
Pia López-Jornet, Juan Berna Mestre, Frank Pina, Angela Aniorte Alegria, Jose Gálvez, Juan de Dios Berna Serna, Is sonoelastography a helpful method of evaluation to diagnose Sjögren's syndrome?, International Journal of Rheumatic Diseases, 22, 2, 2019. Crossref
-
Saccomandi P., Schena E., Diana M., Marescaux J., Costamagna G., Thermal Treatments of Tumors, in Biomedical Engineering Challenges, 2018. Crossref
-
Tu Xiang, Qiu Shi, Chang Tiancong, Jin Kun, Bao Yige, Yang Lu, Wei Qiang, The role of real-time elastography-targeted biopsy in the detection and diagnosis of prostate cancer, Medicine, 97, 12, 2018. Crossref
-
Can Mehmet Erol, Unal Özlem, Kars Meltem Ece, Erten Sukran, Dereli Can Gamze, Duru Necati, Cagil Nurullah, An assessment of ocular elasticity using real time ultrasound and ocular response analyzer in active or remission rheumatoid arthritis, International Ophthalmology, 39, 10, 2019. Crossref
-
Carneiro Felipe, Miranda Eduardo P., Penile Elastography: Current and Future Applications in Sexual Medicine, The Journal of Sexual Medicine, 15, 6, 2018. Crossref
-
Paluch Ł, Noszczyk BH, Walecki J, Osiak K, Kiciński M, Pietruski P, Shear-wave elastography in the diagnosis of ulnar tunnel syndrome, Journal of Plastic, Reconstructive & Aesthetic Surgery, 71, 11, 2018. Crossref
-
Chen Bin-Bin, Li Jian, Guan Ying, Xiao Wei-Wei, Zhao Chong, Lu Tai-Xiang, Han Fei, The value of shear wave elastography in predicting for undiagnosed small cervical lymph node metastasis in nasopharyngeal carcinoma: A preliminary study, European Journal of Radiology, 103, 2018. Crossref
-
Gandhi Jason, Zaidi Saher, Shah Janki, Joshi Gunjan, Khan Sardar Ali, The Evolving Role of Shear Wave Elastography in the Diagnosis and Treatment of Prostate Cancer, Ultrasound Quarterly, 34, 4, 2018. Crossref
-
Zhu Jiang, He Xingdao, Chen Zhongping, Acoustic radiation force optical coherence elastography for elasticity assessment of soft tissues, Applied Spectroscopy Reviews, 54, 6, 2019. Crossref
-
Sassaroli Elisabetta, Crake Calum, Scorza Andrea, Kim Don‐Soo, Park Mi‐Ae, Image quality evaluation of ultrasound imaging systems: advanced B‐modes, Journal of Applied Clinical Medical Physics, 20, 3, 2019. Crossref
-
Liu Dongxu, Hu Zhijian, Wang Ge, Sun Lizhi, Sound Transmission-Based Elastography Imaging, IEEE Access, 7, 2019. Crossref
-
Lamprecht Raphael, Maghzinajafabadi Mohammadali, Semmler Marion, Sutor Alexander, Imaging the Vocal Folds: A Feasibility Study on Strain Imaging and Elastography of Porcine Vocal Folds, Applied Sciences, 9, 13, 2019. Crossref
-
Ji Yonghao, Ruan Litao, Ren Wei, Dun Guoliang, Liu Jianxue, Zhang Yaoren, Wan Qinyun, Stiffness of prostate gland measured by transrectal real-time shear wave elastography for detection of prostate cancer: a feasibility study, The British Journal of Radiology, 92, 1097, 2019. Crossref
-
Cotoi Laura, Amzar Daniela, Sporea Ioan, Borlea Andreea, Navolan Dan, Varcus Flore, Stoian Dana, Shear Wave Elastography versus Strain Elastography in Diagnosing Parathyroid Adenomas, International Journal of Endocrinology, 2020, 2020. Crossref
-
Selladurai Sathiyamoorthy, Verma Abhilash, Thittai Arun K., Toward Quantitative and Operator-independent Quasi-static Ultrasound Elastography: An Ex Vivo Feasibility Study, Ultrasonic Imaging, 42, 4-5, 2020. Crossref
-
dos Santos Djalma Simões, Cardoso Fernando Mitsuyama, Furuie Sérgio Shiguemi, Two-dimensional ultrasonic transducer array for shear wave elastography in deep tissues: a preliminary study, Research on Biomedical Engineering, 36, 3, 2020. Crossref
-
Aruleba Kehinde, Obaido George, Ogbuokiri Blessing, Fadaka Adewale Oluwaseun, Klein Ashwil, Adekiya Tayo Alex, Aruleba Raphael Taiwo, Applications of Computational Methods in Biomedical Breast Cancer Imaging Diagnostics: A Review, Journal of Imaging, 6, 10, 2020. Crossref
-
Chua Alynna X.Y., Hackett Lisa M., Lam Patrick H., Murrell George A.C., The fate of sutures post rotator cuff repair, Journal of Shoulder and Elbow Surgery, 30, 12, 2021. Crossref
-
Liu DongXu, Kruggel Frithjof, Sun LiZhi, Elastography mapped by deep convolutional neural networks, Science China Technological Sciences, 64, 7, 2021. Crossref
-
Hartleif Steffen, Sturm Ekkehard, Chronic Graft Injury, in Pediatric Liver Transplantation, 2021. Crossref
-
Demir Mehmet, Dere Osman, Yağmur İsmail, Katı Bülent, Pelit Eyyup Sabri, Albayrak İbrahim Halil, Çiftçi Halil, Usability of shear wave elastography to predict the success of extracorporeal shock-wave lithotripsy: prospective pilot study, Urolithiasis, 49, 3, 2021. Crossref
-
Oruk Yunus Emre, Çildağ Mehmet Burak, Karaman Can Zafer, Çildağ Songül, Effectiveness of ultrasonography and shear wave sonoelastography in Sjögren syndrome with salivary gland involvement, Ultrasonography, 40, 4, 2021. Crossref
-
Matsuzaki Sachiko, Mechanobiology of the female reproductive system, Reproductive Medicine and Biology, 20, 4, 2021. Crossref
-
Brizzi Giulia, Crepaldi Paola, Roccabianca Paola, Morabito Simona, Zini Eric, Auriemma Edoardo, Zanna Giordana, Strain elastography for the assessment of skin nodules in dogs, Veterinary Dermatology, 32, 3, 2021. Crossref
-
Yang Jin-Ru, Song Yan, Jia Yu-Li, Ruan Li-Tao, Application of multimodal ultrasonography for differentiating benign and malignant cervical lymphadenopathy, Japanese Journal of Radiology, 39, 10, 2021. Crossref
-
FUSCO Pierfrancesco, DI CARLO Stefano, PETRONI Gian M., SCIMIA Paolo, SEPOLVERE Giuseppe, CIASCHI Walter, MARINANGELI Franco, Lung elastosonography for diagnosis and management of COVID-19 pneumonia, Minerva Anestesiologica, 87, 3, 2021. Crossref
-
Abdelwahab Khaled M., Eldery Mohamed Salah, Desoky Esam, El‐Babouly Islam M., Taha Kareem, Saber Sameh, Seleem Mohammed M., Role of shear wave elastography (SWE) in erectile dysfunction patients for evaluation of daily tadalafil treatment outcome, Andrologia, 54, 4, 2022. Crossref
-
Abdelaal Alaaeldien Mohamed Abdelmoniem, El‐Azizi Hatem Mohamed, GamalEl Din Sameh Fayek, Abdulsalam Mohammad Azzazi Omar, Shokr Mohamed Mohamed, Evaluation of the potential role of shear wave elastography as a promising predictor of sperm retrieval in non‐obstructive azoospermic patients: A prospective study, Andrology, 9, 5, 2021. Crossref
-
Hyun Jeongeun, Kim Hae-Won, Leveraging cellular mechano-responsiveness for cancer therapy, Trends in Molecular Medicine, 28, 2, 2022. Crossref
-
Bontzos Georgios, Douglas Vivian Paraskevi, Douglas Konstantinos A.A., Kapsala Zoi, Drakonaki Eleni E., Detorakis Efstathios T., Ultrasound Elastography in Ocular and Periocular Tissues: A Review, Current Medical Imaging Formerly Current Medical Imaging Reviews, 17, 9, 2021. Crossref
-
Guo Ting, He Chao, Venado Aida, Zhou Yong, Extracellular Matrix Stiffness in Lung Health and Disease, in Comprehensive Physiology, 2022. Crossref
-
Lewicki Andrzej, Freeman Simon, Jędrzejczyk Maciej, Dobruch Jakub, Dong Yi, Bertolotto Michele, Dietrich Christoph F., Incidental Findings and How to Manage Them: Testis— A WFUMB Position Paper, Ultrasound in Medicine & Biology, 47, 10, 2021. Crossref
-
Zhang Jisheng, Fan Fan, Zhu Lianqing, Wang Chongyang, Chen Xinyun, Xinxiao Gao, Zhu Jiang, Elasticity measurements of ocular anterior and posterior segments using optical coherence elastography, Optics Express, 30, 9, 2022. Crossref
-
Lorenzon Michele, Spina Erica, Tulipano Di Franco Francesco, Giovannini Ivan, De Vita Salvatore, Zabotti Alen, Salivary Gland Ultrasound in Primary Sjögren’s Syndrome: Current and Future Perspectives, Open Access Rheumatology: Research and Reviews, Volume 14, 2022. Crossref
-
Larocerie-Salgado Juliana, Davidson John, Fenton Paul, Nonoperative Treatment of Dupuytren's Contracture: The Use of Ultrasound Imaging to Assess Efficacy, Journal of Hand and Microsurgery, 2022. Crossref