ISSN Print: 0278-940X
Volumes:Volume 45, 2017 Volume 44, 2016 Volume 43, 2015 Volume 42, 2014 Volume 41, 2013 Volume 40, 2012 Volume 39, 2011 Volume 38, 2010 Volume 37, 2009 Volume 36, 2008 Volume 35, 2007 Volume 34, 2006 Volume 33, 2005 Volume 32, 2004 Volume 31, 2003 Volume 30, 2002 Volume 29, 2001 Volume 28, 2000 Volume 27, 1999 Volume 26, 1998 Volume 25, 1997 Volume 24, 1996 Volume 23, 1995
Critical Reviews™ in Biomedical Engineering
Bone Tissue Engineering: Recent Advances and Challenges
Ami R. Amini
Institute for Regenerative Engineering, Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, CT.
Cato T. Laurencin
Institute for Regenerative Engineering, Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, CT.; Chemical and Biomolecular Engineering, Biomedical Engineering, University of Connecticut, Storrs, CT.
Syam P. Nukavarapu
Institute for Regenerative Engineering, Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, CT. ; Materials Science and Engineering, Biomedical Engineering, University of Connecticut, Storrs, CT.
The worldwide incidence of bone disorders and conditions has trended steeply upward and is expected to double by 2020, especially in populations where aging is coupled with increased obesity and poor physical activity. Engineered bone tissue has been viewed as a potential alternative to the conventional use of bone grafts, due to their limitless supply and no disease transmission. However, bone tissue engineering practices have not proceeded to clinical practice due to several limitations or challenges. Bone tissue engineering aims to induce new functional bone regeneration via the synergistic combination of biomaterials, cells, and factor therapy. In this review, we discuss the fundamentals of bone tissue engineering, highlighting the current state of this field. Further, we review the recent advances of biomaterial and cell-based research, as well as approaches used to enhance bone regeneration. Specifically, we discuss widely investigated biomaterial scaffolds, micro- and nano-structural properties of these scaffolds, and the incorporation of biomimetic properties and/or growth factors. In addition, we examine various cellular approaches, including the use of mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), adult stem cells, induced pluripotent stem cells (iPSCs), and platelet-rich plasma (PRP), and their clinical application strengths and limitations. We conclude by overviewing the challenges that face the bone tissue engineering field, such as the lack of sufficient vascularization at the defect site, and the research aimed at functional bone tissue engineering. These challenges will drive future research in the field.
KEY WORDS: bone tissue engineering stem cells, scaffolds, vascularization, immunomodulation, cell homing, clinical challenges
|Begell Digital Portal||Begell Digital Library||eBooks||Journals||References & Proceedings||Research Collections|