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Critical Reviews™ in Biomedical Engineering
Bone Tissue Engineering: Recent Advances and Challenges
Ami R. Amini
Institute for Regenerative Engineering, Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, CT.
Cato T. Laurencin
Institute for Regenerative Engineering, Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, CT.; Chemical and Biomolecular Engineering, Biomedical Engineering, University of Connecticut, Storrs, CT.
Syam P. Nukavarapu
Institute for Regenerative Engineering, Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, CT. ; Materials Science and Engineering, Biomedical Engineering, University of Connecticut, Storrs, CT.
The worldwide incidence of bone disorders and conditions has trended steeply upward and is expected to double by 2020, especially in populations where aging is coupled with increased obesity and poor physical activity. Engineered bone tissue has been viewed as a potential alternative to the conventional use of bone grafts, due to their limitless supply and no disease transmission. However, bone tissue engineering practices have not proceeded to clinical practice due to several limitations or challenges. Bone tissue engineering aims to induce new functional bone regeneration via the synergistic combination of biomaterials, cells, and factor therapy. In this review, we discuss the fundamentals of bone tissue engineering, highlighting the current state of this field. Further, we review the recent advances of biomaterial and cell-based research, as well as approaches used to enhance bone regeneration. Specifically, we discuss widely investigated biomaterial scaffolds, micro- and nano-structural properties of these scaffolds, and the incorporation of biomimetic properties and/or growth factors. In addition, we examine various cellular approaches, including the use of mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), adult stem cells, induced pluripotent stem cells (iPSCs), and platelet-rich plasma (PRP), and their clinical application strengths and limitations. We conclude by overviewing the challenges that face the bone tissue engineering field, such as the lack of sufficient vascularization at the defect site, and the research aimed at functional bone tissue engineering. These challenges will drive future research in the field.
KEY WORDS: bone tissue engineering stem cells, scaffolds, vascularization, immunomodulation, cell homing, clinical challenges
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