Published 6 issues per year
ISSN Print: 0278-940X
ISSN Online: 1943-619X
Indexed in
Multiscale Modeling of Gastrointestinal Electrophysiology and Experimental Validation
ABSTRACT
Normal gastrointestinal (GI) motility results from the coordinated interplay of multiple cooperating mechanisms, both intrinsic and extrinsic to the GI tract. A fundamental component of this activity is an omnipresent electrical activity termed slow waves, which is generated and propagated by the interstitial cells of Cajal (ICCs). The role of ICC loss and network degradation in GI motility disorders is a significant area of ongoing research. This review examines recent progress in the multiscale modeling framework for effectively integrating a vast range of experimental data in GI electrophysiology, and outlines the prospect of how modeling can provide new insights into GI function in health and disease. The review begins with an overview of the GI tract and its electrophysiology, and then focuses on recent work on modeling GI electrical activity, spanning from cell to body biophysical scales. Mathematical cell models of the ICCs and smooth muscle cell are presented. The continuum framework of monodomain and bidomain models for tissue and organ models are then considered, and the forward techniques used to model the resultant body surface potential and magnetic field are discussed. The review then outlines recent progress in experimental support and validation of modeling, and concludes with a discussion on potential future research directions in this field.
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Du Peng, Paskaranandavadivel Niranchan, O’Grady Greg, Tang Shou-Jiang, Cheng Leo K., A theoretical study of the initiation, maintenance and termination of gastric slow wave re-entry, Mathematical Medicine and Biology, 2014. Crossref
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Peng Du , Yong Cheng Poh , Jee Lean Lim , Gajendiran V., OrGrady G., Buist M. L., Pullan A. J., Cheng L. K., A Preliminary Model of Gastrointestinal Electromechanical Coupling, IEEE Transactions on Biomedical Engineering, 58, 12, 2011. Crossref
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Klemm Lisa, Seydewitz Robert, Böl Markus, Three-Dimensional Multi-Scale Modeling of Electro-Chemomechanical Gastric Smooth Muscle Contraction, in Solid (Bio)mechanics: Challenges of the Next Decade, 24, 2022. Crossref
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Bauer Melanie, Morales-Orcajo Enrique, Klemm Lisa, Seydewitz Robert, Fiebach Victoria, Siebert Tobias, Böl Markus, Biomechanical and microstructural characterisation of the porcine stomach wall: Location- and layer-dependent investigations, Acta Biomaterialia, 102, 2020. Crossref
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Du Peng, O'Grady Gregory, Gao Jerry, Sathar Shameer, Cheng Leo K., Toward the virtual stomach: progress in multiscale modeling of gastric electrophysiology and motility, WIREs Systems Biology and Medicine, 5, 4, 2013. Crossref
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