Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Print: 0278-940X
ISSN Online: 1943-619X

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v39.i4.40
pages 297-318

Role of Airway Recruitment and Derecruitment in Lung Injury

Samir Ghadiali
The Ohio State University
Y. Huang
Department of Biomedical Engineering, Ohio State University, Columbus, Ohio; Davis Heart & Lung Research Institute, Ohio State University, Columbus, Ohio

ABSTRACT

The mechanical forces generated during the ventilation of patients with acute lung injury causes significant lung damage and inflammation. Low-volume ventilation protocols are commonly used to prevent stretch-related injury that occurs at high lung volumes. However, the cyclic closure and reopening of pulmonary airways at low lung volumes, i.e., derecruitment and recruitment, also causes significant lung damage and inflammation. In this review, we provide an overview of how biomedical engineering techniques are being used to elucidate the complex physiological and biomechanical mechanisms responsible for cellular injury during recruitment/derecruitment. We focus on the development of multiscale, multiphysics computational models of cell deformation and injury during airway reopening. These models, and the corresponding in vitro experiments, have been used to both elucidate the basic mechanisms responsible for recruitment/derecruitment injury and to develop alternative therapies that make the epithelium more resistant to injury. For example, models and experiments indicate that fluidization of the cytoskeleton is cytoprotective and that changes in cytoskeletal structure and cell mechanics can be used to mitigate the mechanotransduction of oscillatory pressure into inflammatory signaling. The continued application of biomedical engineering techniques to the problem of recruitment/derecruitment injury may therefore lead to novel and more effective therapies.


Articles with similar content:

Stem Cells: A New Paradigm in Medical Therapeutics
Journal of Long-Term Effects of Medical Implants, Vol.20, 2010, issue 3
Sadanand D. Mankikar
Generation of Lung and Airway Epithelial Cells from Embryonic Stem Cells In Vitro
Critical Reviews™ in Eukaryotic Gene Expression, Vol.26, 2016, issue 1
Hamid Tavanaeimanesh, Mohammad Mehdi Dehghan, Sirous Sadeghian Chaleshtori, Mohammad Reza Mokhber Dezfouli
Collagens of Articular Cartilage: Structure, Function, and Importance in Tissue Engineering
Critical Reviews™ in Biomedical Engineering, Vol.35, 2007, issue 5
Kyriacos A. Athanasiou, Roman M. Natoli, Donald J. Responte
Bacteria-Containing Vacuoles: Subversion of Cellular Membrane Traffic and Autophagy
Critical Reviews™ in Eukaryotic Gene Expression, Vol.25, 2015, issue 2
Bor Luen Tang
Pathogenesis of Multiple Organ Failure in Sepsis
Critical Reviews™ in Immunology, Vol.35, 2015, issue 4
Alexander Zarbock, Jan Rossaint