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Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Print: 0278-940X
ISSN Online: 1943-619X

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v29.i3.150
pages 535-548

Investigation of Blood Flow Microcirculation by Diffusing Wave Spectroscopy

I. V. Meglinskii
Optics Department of the Physical Faculty, N. G. Chernyshevskii Saratov State University, Saratov, Russia
A. N. Korolevich
B. I. Stepanov Institute of Physics, Byelorussian Academy of Sciences, Byelorussia
V. V. Tuchin
Optics Department at N. G. Chernyshevskii Saratov State University, Laser Diagnostics Laboratory of Technical and Living Systems at the Precision Mechanics and Control Institute, Russian Academy of Sciences, Saratov, Russia

ABSTRACT

This article presents a technique and a setup for noninvasive in vivo studies of cutaneous microcirculation. The technique is based on the analysis of intensity fluctuations of scattered coherent light. The analysis is made in terms of diffusing wave Spectroscopy. The developed technique can be used in clinical practice to determine the motion pattern of scattering particles (such as red blood cells) in randomly inhomogeneous media (such as biological tissues). The average size of scattering particles can be comparable to the wavelength of scattered radiation.


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