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Critical Reviews™ in Biomedical Engineering

Published 6 issues per year

ISSN Print: 0278-940X

ISSN Online: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

Indexed in

Effects of Esophageal Stimulation in Patients With Functional Disorders of the Gastrointestinal Tract

Volume 28, Issue 1&2, 2000, pp. 87-93
DOI: 10.1615/CritRevBiomedEng.v28.i12.150
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ABSTRACT

We studied the effects of esophageal electrical stimulation on cortical-evoked potentials (EPs) and power spectrum of heart rate variability (PS/HRV) in patients with diabetes and non-cardiac chest pain (NCCP). We also recorded cognitive-evoked potentials (P300 EPs) in response to an odd-ball stimulation in patients with NCCP. Diabetic patients did not yield reproducible cortical EPs. Their power spectra of heart rate variability (PS/HRV) showed an increased vagal modulation during stimulation. In patients with NCCP the P300 EPs were of greater amplitude (17 ± 3 mV vs. 12 ± 1 mV in controls, p < 0.04), while peak latenceis were slightly elongated in patients (382 ± 22 ms vs. 354 ± 12 ms in controls). The PS/HRV in these patients also showed an increased vagal modulation of the sinus node activity. Our results suggest the following: (1) in patients with diabetes, afferent pathways and processing of sensory signals are likely to be impaired; (2) an increased perception of esophageal stimulation reflects an exaggerated brainstem response and altered cortical processing of visceral sensation in patients with NCCP.

CITED BY
  1. VAN HANDEL DANIEL, FASS RONNIE, The pathophysiology of non-cardiac chest pain, Journal of Gastroenterology and Hepatology, 20, s3, 2005. Crossref

  2. Romero Vzquez J., Jimnez Senz M., Herreras Gutirrez J.M., Afectaci?n esof?gica en enfermedades sist?micas, neurol?gicas y metab?licas. Diabetes mellitus. Esclerodermia, Medicine - Programa de Formaci?n M?dica Continuada Acreditado, 10, 1, 2008. Crossref

  3. Sheps David S., Creed Francis, Clouse Ray E., Chest Pain in Patients With Cardiac and Noncardiac Disease, Psychosomatic Medicine, 66, 6, 2004. Crossref

  4. Hunt Richard H., Tougas Gervais, Evolving concepts in functional gastrointestinal disorders: promising directions for novel pharmaceutical treatments, Best Practice & Research Clinical Gastroenterology, 16, 6, 2002. Crossref

  5. Hobson Anthony R., Aziz Qasim, Brain processing of esophageal sensation in health and disease, Gastroenterology Clinics of North America, 33, 1, 2004. Crossref

  6. Zhao Jingbo, Gregersen Hans, Diabetes-induced mechanophysiological changes in the esophagus, Annals of the New York Academy of Sciences, 1380, 1, 2016. Crossref

  7. Clouse Ray E., Central Nervous System Approaches for Treating Functional Disorders: How, When, and Why?, Journal of Pediatric Gastroenterology and Nutrition, 39, Supplement 3, 2004. Crossref

  8. Zhao Jing-Bo, Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus, World Journal of Gastroenterology, 12, 18, 2006. Crossref

  9. Fass Ronnie, Herschcovici Tiberiu, Non‐Cardiac Chest Pain, in The Esophagus, 2012. Crossref

  10. Fass Ronnie, Hershcovici Tiberiu, The Problem of Heartburn, and Atypical Chest Pain, in Problem‐Based Approach to Gastroenterology and Hepatology, 2012. Crossref

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