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Critical Reviews™ in Biomedical Engineering

Published 6 issues per year

ISSN Print: 0278-940X

ISSN Online: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

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Bone Formation Into Surface Phosphonylated Polymeric Implants

Volume 28, Issue 3&4, 2000, pp. 377-382
DOI: 10.1615/CritRevBiomedEng.v28.i34.50
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ABSTRACT

Through the use of two animal models, the present study demonstrates the ability of phosphonylated surfaces to bind bone. In one model, surface-treated polypropylene (PP) and polyethylene (PE) were implanted in the medial cortex of the goat tibia. In the second model, surface-treated poly(ether-ether ketone) (PEEK) and carbon fiber-reinforced PEEK (CFR-PEEK) were implanted through both cortices of the goat mandible. Selected rods of all material types were microtextured using crystallization induced microphase separation, a method for the formation of continuous, open-cell microporous surfaces in thermoplastic polymers. Microtextured and smooth rods were phosphonylated, and calcium was subsequently introduced to the phosphonylated surface by incubating the samples in a saturated solution of calcium oxide. For all substrate materials tested, phosphonylation and calcium posttreatment resulted in an increased propensity for bone binding and apposition, as measured by push out test. Microtextured PP, PE, and CFR-PEEK surfaces that were further phosphonylated and calcium treated resulted in test samples with an increased interracial strength.

CITED BY
  1. Shalaby Shalaby, Anneaux Bruce, Physicochemical Modification of Polymers for Bone-Implant Osseointegration, in Polymers for Dental and Orthopedic Applications, 20065340, 2006. Crossref

  2. Revell P.A., Biological response to artificial discs, in Biomaterials for Spinal Surgery, 2012. Crossref

  3. Saito Naoto, Aoki Kaoru, Usui Yuki, Shimizu Masayuki, Hara Kazuo, Narita Nobuyo, Ogihara Nobuhide, Nakamura Koichi, Ishigaki Norio, Kato Hiroyuki, Haniu Hisao, Taruta Seiichi, Ahm Kim Yoong, Endo Morinobu, Application of carbon fibers to biomaterials: A new era of nano-level control of carbon fibers after 30-years of development, Chemical Society Reviews, 40, 7, 2011. Crossref

  4. Shalaby Waleed S.W., Anneaux Bruce L., Bone–Implant: Polymer Physicochemical Modification for Osseointegration, in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2016. Crossref

  5. Shalaby Waleed S.W., Anneaux Bruce L., Bone–Implant: Polymer Physicochemical Modification for Osseointegration, in Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2017. Crossref

  6. Suska Felicia, Omar Omar, Emanuelsson Lena, Taylor Mark, Gruner Philipp, Kinbrum Amy, Hunt Duncan, Hunt Trevor, Taylor Andy, Palmquist Anders, Enhancement of CRF-PEEK osseointegration by plasma-sprayed hydroxyapatite: A rabbit model, Journal of Biomaterials Applications, 29, 2, 2014. Crossref

  7. Revell Peter A., The healing response to implants used in joint replacement, in Joint Replacement Technology, 2021. Crossref

  8. Revell P.A., The healing response to implants used in joint replacement, in Joint Replacement Technology, 2014. Crossref

  9. Saravi Babak, Flohr Anselm, Patzelt Sebastian B., Spies Benedikt C., Hazard Derek, Kohal Ralf J., Fatigue and Fracture Resistance Testing of Polyether Ether Ketone (PEEK) Implant Abutments in an Ex Vivo Chewing Simulator Model, Materials, 15, 19, 2022. Crossref

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