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Critical Reviews™ in Biomedical Engineering

Published 6 issues per year

ISSN Print: 0278-940X

ISSN Online: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

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The Role of Urea Kinetic Modeling in Assessing the Adequacy of Dialysis

Volume 32, Issue 5&6, 2004, 80 pages
DOI: 10.1615/CritRevBiomedEng.v32.i56.30
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ABSTRACT

The adequacy of dialysis based on urea kinetic modeling has more than 20 years of history. Its methodological approach has demonstrated a strong capacity to improve the outcomes of the dialysis therapy. However, recent results of clinical interventional studies and necessary advances in new models of dialysis schemes, particularly daily and nocturnal hemodialysis, have led to the question if whether that methodology is suitable to address current challenges. This work tries to reach an answer to that question. The major conclusion is that urea kinetic modeling provides an extraordinary starting point to both keeping the clinical support to physicians and building new pharmacokinetic and physiological models that throw light on the understanding of the basic mechanisms that underlie the chronic renal disease, in a synergetic manner. Despite this promising expectation, misuse and improper extensions of urea kinetic modeling may jeopardize its credibility to nephrologists. Our concern about this issue emerges mainly from the analysis of recent attempts to extend this methodology to more frequent renal replacement therapies.

CITED BY
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  2. Prado Manuel, Roa Laura, Combining Dialysate and Blood Recirculation to Boost Uremic Toxin Removal: Theory and Simulation Study, Artificial Organs, 31, 12, 2007. Crossref

  3. Roa Laura, Prado Manuel, Simulation Languages, in Wiley Encyclopedia of Biomedical Engineering, 2006. Crossref

  4. Prado Manuel, Roa Laura M., Palma Alfonso, Milán José A., Improving Hollow Fiber Dialyzer Efficiency with a Recirculating Dialysate System II: Comparison Against Two-Chamber Dialysis Systems, Annals of Biomedical Engineering, 33, 11, 2005. Crossref

  5. Prado Manuel, Roa Laura M., Reina-Tosina Javier, Viability study of a personalized and adaptive knowledge-generation telehealthcare system for nephrology (NEFROTEL), International Journal of Medical Informatics, 75, 9, 2006. Crossref

  6. Lowrie Edmund G., The Kinetic Behaviors of Urea and Other Marker Molecules During Hemodialysis, American Journal of Kidney Diseases, 50, 2, 2007. Crossref

  7. Prado M., Roa L.M., Virtual modelling of compartmental pharmacokinetic systems, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, 2005. Crossref

  8. Prado Manuel, Roa Laura M., Palma Alfonso, Milán José A., Double-perspective measurement of the hemodialysis dose by blood-side mathematical methods, in World Congress on Medical Physics and Biomedical Engineering 2006, 14, 2007. Crossref

  9. Prado-Velasco Manuel, Flow Modeling of Hollow Fiber Dialyzers, in Modelling and Control of Dialysis Systems, 404, 2013. Crossref

  10. Prado Manuel, Roa Laura M., Palma Alfonso, Milen Jose A., Double target comparison of blood-side methods for measuring the hemodialysis dose, Kidney International, 68, 6, 2005. Crossref

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