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Plasma Medicine

ISSN Print: 1947-5764
ISSN Online: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2017019666
pages 85-96

Immune Cells Enhance Selectivity of Nanosecond-Pulsed DBD Plasma Against Tumor Cells

Abraham Lin
Nyheim Drexel Plasma Institute, Drexel University, Philadelphia, PA
Billy Truong
Nyheim Drexel Plasma Institute, Drexel University, Philadelphia, PA
Gregory Fridman
Nyheim Drexel Plasma Institute, Drexel University, Philadelphia, PA
Alexander A. Fridman
Nyheim Drexel Plasma Institute, Drexel University, Philadelphia, PA
Vandana Miller
Nyheim Drexel Plasma Institute, Drexel University, Philadelphia, PA

ABSTRACT

Cancer immunotherapy is a promising strategy that engages the patient's immune system to kill cancer cells selectively while sparing normal tissue. Treatment of macrophages with a nanosecond-pulsed dielectric barrier discharge directly enhanced their cytotoxic activity against tumor cells but not normal cells. These results underscore the clinical potential of plasma for cancer immunotherapy.