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Plasma Medicine

ISSN Print: 1947-5764
ISSN Online: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2017019666
pages 85-96

Immune Cells Enhance Selectivity of Nanosecond-Pulsed DBD Plasma Against Tumor Cells

Abraham Lin
University of Antwerp, Department of Chemistry, Antwerp, Belgium
Billy Truong
Department of Biology, College of Arts & Sciences, Drexel University, Philadelphia, Pennsylvania
Gregory Fridman
Drexel University, C. & J. Nyheim, Camden, NJ 08103
Alexander A. Fridman
Drexel University, Nyheim Plasma Institute, Camden, New Jersey, USA
Vandana Miller
Drexel University, Nyheim Plasma Institute, Camden, New Jersey, USA

ABSTRACT

Cancer immunotherapy is a promising strategy that engages the patient's immune system to kill cancer cells selectively while sparing normal tissue. Treatment of macrophages with a nanosecond-pulsed dielectric barrier discharge directly enhanced their cytotoxic activity against tumor cells but not normal cells. These results underscore the clinical potential of plasma for cancer immunotherapy.