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Plasma Medicine

ISSN Print: 1947-5764
ISSN Online: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2017019666
pages 85-96

Immune Cells Enhance Selectivity of Nanosecond-Pulsed DBD Plasma Against Tumor Cells

Abraham Lin
C. & J. Nyheim Plasma Institute, Drexel University, 200 Federal Street, Suite 500, Camden, New Jersey
Billy Truong
Department of Biology, College of Arts & Sciences, Drexel University, Philadelphia, Pennsylvania
Gregory Fridman
Nyheim Drexel Plasma Institute, Drexel University, Philadelphia, PA
Alexander A. Fridman
Nyheim Drexel Plasma Institute, Drexel University, Philadelphia, PA
Vandana Miller
C. & J. Nyheim Plasma Institute, Drexel University, 200 Federal Street, Suite 500, Camden, New Jersey

ABSTRACT

Cancer immunotherapy is a promising strategy that engages the patient's immune system to kill cancer cells selectively while sparing normal tissue. Treatment of macrophages with a nanosecond-pulsed dielectric barrier discharge directly enhanced their cytotoxic activity against tumor cells but not normal cells. These results underscore the clinical potential of plasma for cancer immunotherapy.