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Comparative Study of Cancer Treatment Potential Effects of Tumor-Treating Fields and Cold Atmospheric Plasma

Volume 10, Issue 1, 2020, pp. 45-59
DOI: 10.1615/PlasmaMed.2020033045
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Xiaoliang Yao
The George Washington University, Washington, DC 20052
Isaac Goldstein
University of California at Berkeley, Berkeley, California 94720
Li Lin
Department of Pathology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Rd, Nanjing 010011, China; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA
Jonathan H. Sherman
Neurological Surgery, The George Washington University, Foggy Bottom South Pavilion, 22nd Street NW, 7th Floor, Washington, DC 20052, USA
Michael Keidar
Department of Mechanical and Aerospace Engineering, The George Washington University, Science and Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052, USA

ABSTRACT

Tumor-treating fields (TTFields) therapy is well known and approved by the Food and Drug Administration for treatment of adult patients who suffer with glioblastoma. The method uses low-intensity and intermediate-frequency alternating electric fields to produce an inhibitory effect on cancerous cells. However, it involves 24 h of treatment time to produce anticancer effects. A new modality of cancer treatment called cold plasma therapy (CPT) has been shown both in vitro and in mice models to significantly treat dozens of cancer types. CPT is based on the therapeutic effect of cold atmospheric plasma (CAP), a type of ionized gas that operates at close to room temperature and provides electromagnetic radiation as well as reactive oxygen and nitrogen species, both cytotoxic to cancer cells. With this study, after investigating the anticancer effects of TTFields and CAP on glioblastoma cells, we have found that CAP has superior ability to inhibit cancer.

KEY WORDS: plasma
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CITED BY

  1. Yao Xiaoliang, Lin Li, Soni Vikas, Gjika Eda, Sherman Jonathan H., Yan Dayun, Keidar Michael, Sensitization of glioblastoma cells to temozolomide by a helium gas discharge tube, Physics of Plasmas, 27, 11, 2020. Crossref

  2. Soni Vikas, Adhikari Manish, Simonyan Hayk, Lin Li, Sherman Jonathan H., Young Colin N., Keidar Michael, In Vitro and In Vivo Enhancement of Temozolomide Effect in Human Glioblastoma by Non-Invasive Application of Cold Atmospheric Plasma, Cancers, 13, 17, 2021. Crossref

  3. Soni Vikas, Adhikari Manish, Lin Li, Sherman Jonathan H., Keidar Michael, Theranostic Potential of Adaptive Cold Atmospheric Plasma with Temozolomide to Checkmate Glioblastoma: An In Vitro Study, Cancers, 14, 13, 2022. Crossref

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