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Plasma Medicine

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ISSN Print: 1947-5764

ISSN Online: 1947-5772

SJR: 0.216 SNIP: 0.263 CiteScore™:: 1.4 H-Index: 24

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Micro-Sized Cold Atmospheric Plasma Source for Brain and Breast Cancer Treatment

Volume 8, Issue 2, 2018, pp. 203-215
DOI: 10.1615/PlasmaMed.2018026588
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ABSTRACT

Micro-sized cold atmospheric plasma (µCAP) has been developed to expand the applications of CAP in cancer therapy. In this paper, µCAP devices with different nozzle lengths were applied to investigate effects on both brain (glioblastoma U87) and breast (MDA-MB-231) cancer cells. Various diagnostic techniques were employed to evaluate the parameters of µCAP devices with different lengths. Parameters included potential distribution, electron density, and optical emission spectroscopy. The generation of short- and long-lived species (such as hydroxyl radical [·OH], superoxide [O2], hydrogen peroxide [H2O2], and nitrite [NO2]) were studied. These data revealed that µCAP treatment with a 20 mm long tube has a stronger effect than that of the 60 mm tube because of the synergetic effects of reactive species and free radicals. Reactive species generated by µCAP enhanced tumor cell death that was dose-dependent and nonspecific to tumor cell type.

CITED BY
  1. Li Wentong, Yu Hongli, Ding Dejun, Chen Zhitong, Wang Yonghong, Wang Saisai, Li Xujing, Keidar Michael, Zhang Weifen, Cold atmospheric plasma and iron oxide-based magnetic nanoparticles for synergetic lung cancer therapy, Free Radical Biology and Medicine, 130, 2019. Crossref

  2. Braný Dušan, Dvorská Dana, Halašová Erika, Škovierová Henrieta, Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine, International Journal of Molecular Sciences, 21, 8, 2020. Crossref

  3. Lafontaine Julie, Boisvert Jean-Sébastien, Glory Audrey, Coulombe Sylvain, Wong Philip, Synergy between Non-Thermal Plasma with Radiation Therapy and Olaparib in a Panel of Breast Cancer Cell Lines, Cancers, 12, 2, 2020. Crossref

  4. Mitra Sarmistha, Kaushik Neha, Moon Il Soo, Choi Eun Ha, Kaushik Nagendra Kumar, Utility of Reactive Species Generation in Plasma Medicine for Neuronal Development, Biomedicines, 8, 9, 2020. Crossref

  5. Chen Zhitong, Xu Rong-Guang, Chen Peijian, Wang Qiu, Potential Agricultural and Biomedical Applications of Cold Atmospheric Plasma-Activated Liquids With Self-Organized Patterns Formed at the Interface, IEEE Transactions on Plasma Science, 48, 10, 2020. Crossref

  6. Haralambiev Lyubomir , Wien Lasse , Gelbrich Nadine , Lange J�rn , Bakir Sinan , Kramer Axel , Burchardt Martin , Ekkernkamp Axel , G�mbel Denis , Stope Matthias , Cold atmospheric plasma inhibits the growth of osteosarcoma cells by inducing apoptosis, independent of the device used, Oncology Letters, 2019. Crossref

  7. Chen Zhitong, Wirz Richard E., Cold Atmospheric Plasma (CAP) Technology and Applications, 2021. Crossref

  8. Wang Peiyu, Zhou Renwu, Thomas Patrick, Zhao Liqian, Zhou Rusen, Mandal Susmita, Jolly Mohit, Richard Derek, Rehm Bernd, Ostrikov Kostya, Dai Xiaofeng, Williams Elizabeth, Thompson Erik, Epithelial-to-Mesenchymal Transition Enhances Cancer Cell Sensitivity to Cytotoxic Effects of Cold Atmospheric Plasmas in Breast and Bladder Cancer Systems, Cancers, 13, 12, 2021. Crossref

  9. Braný Dušan, Dvorská Dana, Strnádel Ján, Matáková Tatiana, Halašová Erika, Škovierová Henrieta, Effect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy, International Journal of Molecular Sciences, 22, 22, 2021. Crossref

  10. Soni Vikas, Adhikari Manish, Simonyan Hayk, Lin Li, Sherman Jonathan H., Young Colin N., Keidar Michael, In Vitro and In Vivo Enhancement of Temozolomide Effect in Human Glioblastoma by Non-Invasive Application of Cold Atmospheric Plasma, Cancers, 13, 17, 2021. Crossref

  11. Harley Juliette C., Suchowerska Natalka, McKenzie David R., Cancer treatment with gas plasma and with gas plasma–activated liquid: positives, potentials and problems of clinical translation, Biophysical Reviews, 12, 4, 2020. Crossref

  12. Chen Zhitong, Chen Guojun, Obenchain Richard, Zhang Rui, Bai Fan, Fang Tianxu, Wang Hanwen, Lu Yingjie, Wirz Richard E., Gu Zhen, Cold atmospheric plasma delivery for biomedical applications, Materials Today, 54, 2022. Crossref

  13. Gott Ryan Patrick, Xu Kunning Gabriel, OH Production and Jet Length of an Atmospheric-Pressure Plasma Jet for Soft and Biomaterial Treatment, IEEE Transactions on Plasma Science, 47, 11, 2019. Crossref

  14. Kumar Dubey Sunil, Dabholkar Neha, Narayan Pal Udit, Singhvi Gautam, Kumar Sharma Navin, Puri Anu, Kesharwani Prashant, Emerging innovations in cold plasma therapy against cancer: A paradigm shift, Drug Discovery Today, 27, 9, 2022. Crossref

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