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Plasma Medicine

ISSN Print: 1947-5764
ISSN Online: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.v1.i1.40
pages 45-54

Targeted Cancer Treatment Using Anti-EGFR and -TFR Antibody-Conjugated Gold Nanoparticles Stimulated by Nonthermal Air Plasma

GonJun Kim
Department of Electronic and Electrical Engineering, Pohang University of Science and Technology, SOUTH KOREA
S. R. Park
Department of Oral Anatomy, School of Dentistry, Pusan National University, Republic of Korea
G. C. Kim
Department of Oral Anatomy, School of Dentistry, Pusan National University, Republic of Korea
Jae Koo (J.K.) Lee
Department of Electronic and Electrical Engineering, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea

ABSTRACT

Nonthermal air plasma killed G361 melanoma and SCC25 oral cancer cells targeted by antibody-conjugated gold nanoparticles. Although plasma alone is effective in killing cancerous cells, it also affects normal cells during the treatment process. For enhanced effects, gold nanoparticles and cancer-specific antibodies were pretreated before plasma treatment. Gold nanoparticles taken up by the cancerous cells are stimulated by the plasma treatment. Stimulation of gold nanoparticles results in an increase in death rate of cancerous cells. The selectivity of the killing process is achieved by conjugating gold nanoparticles with antiepidermal growth factor receptor and transferrin receptor antibodies. These conjugates can bind specifically to cancer cells. Gold nanoparticles stimulated by plasma kill these cancerous cells effectively. In this way, the killing efficiency of the plasma treatment process in the presence of conjugates is amplified about 18 times compared to the plasma treatment in the absence of conjugates. This technique shows the possibility of using plasma therapy for killing cancer cells selectively and effectively.