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Plasma Medicine
SJR: 0.278 SNIP: 0.183 CiteScore™: 0.57

ISSN Print: 1947-5764
ISSN Online: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2018019483
pages 347-381

Plasma Irradiation Effects to Intra-Abdominal Organs Compared with Adhesion Mouse Model

Keita Soda
Research Center for Advanced Science and Technology, Department of Quantitative Biology and Medicine, The University of Tokyo, Japan
Hiroharu Yamashita
Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Japan
Kyungho Chang
The Anesthesiology and Pain Relief Center, University of Tokyo Hospital, Japan
Takeshi Kawamura
Isotope Science Center, The University of Tokyo, Japan
Takao Hamakubo
Research Center for Advanced Science and Technology, Department of Quantitative Biology and Medicine, The University of Tokyo, Japan
Nobuyuki Shimizu
Sanno Hospital, International University of Health and Welfare, Tokyo, Japan

ABSTRACT

In this study, we evaluated the effects of plasma irradiation on intra-abdominal organs using low-energy atmospheric-pressure plasma (LEAPP) compared to cauterization in the mouse adhesion model. Plasma irradiation of the cecum caused an increase of inflammatory proteins, such as serum amyloid proteins, inter-α-trypsin inhibitor, and lactoferrin, in ascites. Plasma irradiation of the cecum and cauterization of the cecum induced mRNA expression of the pro-inflammatory cytokine IL-6. On the other hand, induction of lactoferrin in the cecum was lower with plasma irradiation than with cauterization. In addition, few inflammatory cells infiltrated the cecum after plasma irradiation compared with cauterization. We also demonstrated that very few adhesions formed after plasma irradiation compared to the mouse adhesion model. Furthermore, plasma irradiation is involved in IL-10 induction in blood plasma. Taken together, these results indicate that the reduced inflammatory effects of LEAPP should result in decreased formation of adhesions in tissues in the abdominal cavity.