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Plasma Medicine

ISSN Print: 1947-5764
ISSN Online: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2014011904
pages 29-36

Effect of Active Radical Production on Plasma Degradation of Phorbol 12-Myristate 13-Acetate in Methanolic and Aqueous Solution

Hiroto Matsuura
Osaka Prefecture University
Y. Onishi
Osaka Prefecture University, Gakuen-cho 1-2, Sakai Naka-ku, 599-8570, Japan;
S. Kongmany
Osaka Prefecture University, Gakuen-cho 1-2, Sakai Naka-ku, 599-8570, Japan; National University of Laos, Vientiane Capital, 7322, Lao PDR
Y. Maeda
Osaka Prefecture University, Gakuen-cho 1-2, Sakai Naka-ku, 599-8570, Japan;
M. Furuta
Osaka Prefecture University, Gakuen-cho 1-2, Sakai Naka-ku, 599-8570, Japan;
K. Imamura
Osaka Prefecture University, Gakuen-cho 1-2, Sakai Naka-ku, 599-8570, Japan;
S. Okuda
Osaka Prefecture University, Gakuen-cho 1-2, Sakai Naka-ku, 599-8570, Japan;

ABSTRACT

In this study, we examine the degradation of phorbol esters with atmospheric pressure plasma and, in particular, the highly tolerant phorbol 12-myristate 13-acetate (PMA) molecule. We determined the degradation mechanism by analyzing the structural information of the by-product obtained using mass spectrometry. The plasma source was also improved to generate more active radicals, thereby enhancing the degradation of PMA.