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Plasma Medicine
SJR: 0.198 SNIP: 0.183 CiteScore™: 0.57

ISSN Print: 1947-5764
ISSN Online: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2014011974
pages 101-115

Antibacterial Efficacy and Cytotoxicity of Silver Nanoparticle Based Coatings Facilitated by a Plasma Polymer Interlayer

Shima Taheri
School of Engineering, University of South Australia, Mawson Lakes, SA 5095 Australia
Alex Cavallaro
School of Engineering, University of South Australia, Mawson Lakes, SA 5095 Australia
Mary Barton
School of Pharmacy and Medical Sciences, University of South Australia, SA 5000, Australia
Jason D, Whittle
School of Engineering, University of South Australia, Mawson Lakes, SA 5095 Australia
Peter Majewski
School of Engineering, University of South Australia, Mawson Lakes, SA 5095 Australia
Louise E. Smith
Mawson Institute, University of South Australia, Mawson Lakes, SA 5095 Australia
Krasimir Vasilev
School of Engineering, University of South Australia, Mawson Lakes, SA 5095 Australia

ABSTRACT

Antibacterial coatings have been accepted as a potent solution to the problem of medical-device-associated infections, which affect millions of patients worldwide. In this work, we present silver-nanoparticle-based antibacterial coatings that are highly potent against medically relevant bacteria such as S. epidermidis and S. aureus but do not have apparent cytotoxicity to primary human fibroblast cells. The silver nanoparticles used in the coatings are synthesized in the presence of trisodium citrate. At a given moment, 2-mercaptosuccinc acid is added to allow for reduction of nanoparticle size and to provide the well-defined surface architecture necessary for controllable surface immobilization. Important for application, the technology is facilitated by a functional-plasma-deposited polymer interlayer. This makes it applicable to the surface of medical devices manufactured from any type of material.


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