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International Journal for Multiscale Computational Engineering
IF: 1.016 5-Year IF: 1.194 SJR: 0.452 SNIP: 0.68 CiteScore™: 1.18

ISSN Print: 1543-1649
ISSN Online: 1940-4352

International Journal for Multiscale Computational Engineering

DOI: 10.1615/IntJMultCompEng.2011002360
pages 189-211


Dominique Chapelle
INRIA, Rocquencourt, BP 105, 78153 Le Chesnay cedex, France
P. Le Tallec
Ecole Polytechnique, 91128 Palaiseau cedex, France
P. Moireau
INRIA, Rocquencourt, BP 105, 78153 Le Chesnay cedex, France
M. Sorine
INRIA, Rocquencourt, BP 105, 78153 Le Chesnay cedex, France


In this paper, we propose a muscle tissue model-valid for striated muscles, in general, and for the myocardium, in particular-based on a multiscale physiological description. This model extends and refines an earlier-proposed formulation by allowing one to account for all major energy exchanges and balances, from the chemical activity coupled with oxygen supply to the production of actual mechanical work, namely, the biological function of the tissue. We thus perform a thorough analysis of the energy mechanisms prevailing at the various scales and proceed to propose a complete discretization strategy-in time and space-respecting the same balance laws. This will be crucial in future works to adequately model the many important physiological-normal and pathological-phenomena associated with these energy considerations.


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