Library Subscription: Guest
Atomization and Sprays

Published 12 issues per year

ISSN Print: 1044-5110

ISSN Online: 1936-2684

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00095 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.28 SJR: 0.341 SNIP: 0.536 CiteScore™:: 1.9 H-Index: 57

Indexed in

AN ATOMIZER TO GENERATE MONODISPERSE DROPLETS FROM HIGH VAPOR PRESSURE LIQUIDS

Volume 26, Issue 2, 2016, pp. 121-134
DOI: 10.1615/AtomizSpr.2015011631
Get accessGet access

ABSTRACT

This work describes an atomizer capable of generating monodisperse droplets of high vapor pressure liquids such as HFA227ea and HFA134a. This atomizer is expected to be a useful tool in future fundamental explorations of the mechanics of these highly dynamic aerosols. Hydrofluoroalkanes (HFAs) are the most common propellants in metered dose inhalers (MDIs), which are themselves the most common delivery method for pulmonary disease medications. As a result of the high vapor pressure of these fluids, generation of monodisperse droplets and their study are not possible with previously existing monodisperse atomizers due to fluid flashing when exposed to ambient conditions. The new atomizer uses a piezoelectric transducer to disintegrate the propellant jet, a cooling circuit with a low-temperature limit of −30°C to reduce propellant vapor pressure, and a high-pressure feed system (up to 2.7 MPa) to keep the propellant in the liquid phase, thereby avoiding flash atomization. In the current setup, the diameter of the generated droplets was monitored with a laser scattering system (using Fraunhofer diffraction theory) to optimize the operating parameters of the setup (for example, the actuation frequency and amplitude of the piezoelectric transducer). This monitoring system allowed for the measurement of droplet geometric diameter, spacing, and velocity. The capabilities of the atomizer for generating monodisperse droplets are demonstrated by a case study in which monodisperse dry particles of beclomethasone dipropionate (BDP) are generated using a solution of BDP, ethanol co-solvent, and HFA134a propellant.

CITED BY
  1. Ivey James W., Bhambri Pallavi, Church Tanya K., Lewis David A., McDermott Mark T., Elbayomy Shereen, Finlay Warren H., Vehring Reinhard, Humidity affects the morphology of particles emitted from beclomethasone dipropionate pressurized metered dose inhalers, International Journal of Pharmaceutics, 520, 1-2, 2017. Crossref

  2. Wang Hui, Bhambri Pallavi, Ivey James, Vehring Reinhard, Design and pharmaceutical applications of a low-flow-rate single-nozzle impactor, International Journal of Pharmaceutics, 533, 1, 2017. Crossref

  3. Ivey James W., Bhambri Pallavi, Church Tanya K., Lewis David A., Vehring Reinhard, Experimental investigations of particle formation from propellant and solvent droplets using a monodisperse spray dryer, Aerosol Science and Technology, 52, 6, 2018. Crossref

  4. Wang Hui, Nobes David S., Vehring Reinhard, Particle Surface Roughness Improves Colloidal Stability of Pressurized Pharmaceutical Suspensions, Pharmaceutical Research, 36, 3, 2019. Crossref

  5. Baldelli Alberto, Jeronimo Matthew, Tinney Matthew, Bartlett Karen, Real-time measurements of formaldehyde emissions in a gross anatomy laboratory, SN Applied Sciences, 2, 4, 2020. Crossref

  6. Taylor Judith A., McLoughlin Rory, Sandford John, Bevan Ruth, Aldred David, Legionella species: A potential problem associated with rain water harvesting systems?, Indoor and Built Environment, 30, 6, 2021. Crossref

  7. Baldelli Alberto, Ou Junfei, Barona David, Li Wen, Amirfazli A., Sprayable, Superhydrophobic, Electrically, and Thermally Conductive Coating, Advanced Materials Interfaces, 8, 2, 2021. Crossref

  8. Wang Zheng, Wang Hui, Vehring Reinhard, Leucine enhances the dispersibility of trehalose-containing spray-dried powders on exposure to a high-humidity environment, International Journal of Pharmaceutics, 601, 2021. Crossref

  9. Baldelli Alberto, Ou Junfei, Li Wen, Amirfazli Alidad, Spray-On Nanocomposite Coatings: Wettability and Conductivity, Langmuir, 36, 39, 2020. Crossref

  10. Baldelli Alberto, Wells Simon, Pratap-Singh Anubhav, Impact of Product Formulation on Spray-Dried Microencapsulated Zinc for Food Fortification, Food and Bioprocess Technology, 14, 12, 2021. Crossref

  11. Baldelli Alberto, Bschaden Ben, Amirfazli Alidad, Sameoto Dan, Reproducibility of superhydrophobic and oleophobic polymeric micro surface topographies, Surface Topography: Metrology and Properties, 8, 4, 2020. Crossref

  12. Wang Zheng, Ordoubadi Mani, Wang Hui, Vehring Reinhard, Morphology and formation of crystalline leucine microparticles from a co-solvent system using multi-orifice monodisperse spray drying, Aerosol Science and Technology, 55, 8, 2021. Crossref

Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain