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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Heparan Sulfate Proteoglycans: Key Players in Cartilage Biology

Volume 15, Issue 1, 2005, pp. 29-48
DOI: 10.1615/CritRevEukaryotGeneExpr.v15.i1.30
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ABSTRACT

The extracellular matrix (ECM) plays a fundamental role in skeletal patterning and formation of the vertebrate skeleton. This review focuses on the fundamental roles associated with heparan sulfate (HS) proteoglycans in the ECM during cartilage development, which include regulation of gene expression, presentation of growth factors, establishment of morphogen gradients, and modulation of blood homeostasis. The importance of enzymes involved in biosynthesis and assembly of heparan sulfate is also discussed. Finally, the current evidence for functions of individual HS proteoglycans and biosynthetic enzymes based upon human genetic mutation associations with disease and genetic manipulation in transgenic mice is presented. These findings highlight the important role played by HS proteoglycans, such as perlecan, in cartilage development and skeletal growth.

CITED BY
  1. Melrose James, Hayes Anthony J., Whitelock John M., Little Christopher B., Perlecan, the “jack of all trades” proteoglycan of cartilaginous weight-bearing connective tissues, BioEssays, 30, 5, 2008. Crossref

  2. Kirn-Safran Catherine, Farach-Carson Mary C., Carson Daniel D., Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans, Cellular and Molecular Life Sciences, 66, 21, 2009. Crossref

  3. Lamoureux François, Baud'huin Marc, Duplomb Laurence, Heymann Dominique, Rédini Françoise, Proteoglycans: key partners in bone cell biology, BioEssays, 29, 8, 2007. Crossref

  4. Gomes Ronald R., Joshi Sonali S., Farach-Carson Mary C., Carson Daniel D., Ribozyme-mediated perlecan knockdown impairs chondrogenic differentiation of C3H10T1/2 fibroblasts, Differentiation, 74, 1, 2006. Crossref

  5. Savorè Cristiana, Zhang Chu, Muir Caroline, Liu Riting, Wyrwa Jeffrey, Shu Jun, Zhau Haiyen E., Chung Leland W.K., Carson Daniel D., Farach-Carson Mary C., Perlecan Knockdown in Metastatic Prostate Cancer Cells Reduces Heparin-binding Growth Factor Responses in vitro and Tumor Growth in vivo, Clinical & Experimental Metastasis, 22, 5, 2005. Crossref

  6. Jha Amit K., Malik Manisha S., Farach-Carson Mary C., Duncan Randall L., Jia Xinqiao, Hierarchically structured, hyaluronic acid-based hydrogel matrices via the covalent integration of microgels into macroscopic networks, Soft Matter, 6, 20, 2010. Crossref

  7. Muir Caroline, Chung Leland W. K., Carson Daniel D., Farach-Carson Mary C., Hypoxia increases VEGF-A production by prostate cancer and bone marrow stromal cells and initiates paracrine activation of bone marrow endothelial cells, Clinical & Experimental Metastasis, 23, 1, 2006. Crossref

  8. Jha Amit K., Yang Weidong, Kirn-Safran Catherine B., Farach-Carson Mary C., Jia Xinqiao, Perlecan domain I-conjugated, hyaluronic acid-based hydrogel particles for enhanced chondrogenic differentiation via BMP-2 release, Biomaterials, 30, 36, 2009. Crossref

  9. Brown A.J., Alicknavitch M., D’Souza S.S., Daikoku T., Kirn-Safran C.B., Marchetti D., Carson D.D., Farach-Carson M.C., Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation, Bone, 43, 4, 2008. Crossref

  10. Ratzka Andreas, Kalus Ina, Moser Markus, Dierks Thomas, Mundlos Stefan, Vortkamp Andrea, Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development, Developmental Dynamics, 237, 2, 2008. Crossref

  11. Li Jingting, Pei Ming, Optimization of an In Vitro Three-Dimensional Microenvironment to Reprogram Synovium-Derived Stem Cells for Cartilage Tissue Engineering, Tissue Engineering Part A, 17, 5-6, 2011. Crossref

  12. Miller Rachel E., Grodzinsky Alan J., Cummings Kiersten, Plaas Anna H. K., Cole Ada A., Lee Richard T., Patwari Parth, Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate, Arthritis & Rheumatism, 62, 12, 2010. Crossref

  13. Farach-Carson Mary C., Brown Anissa J., Lynam Megan, Safran Jeffrey B., Carson Daniel D., A novel peptide sequence in perlecan domain IV supports cell adhesion, spreading and FAK activation, Matrix Biology, 27, 2, 2008. Crossref

  14. Tong Zhixiang, Sant Shilpa, Khademhosseini Ali, Jia Xinqiao, Controlling the Fibroblastic Differentiation of Mesenchymal Stem Cells Via the Combination of Fibrous Scaffolds and Connective Tissue Growth Factor, Tissue Engineering Part A, 17, 21-22, 2011. Crossref

  15. Tong Zhixiang, Jia Xinqiao, Biomaterial-based strategies for the engineering of mechanically active soft tissues, MRS Communications, 2, 2, 2012. Crossref

  16. Wahba O.M., Raghib A.M., Megahed E.M., Hussein M.M., Expression of perlecan, syndecan-1 and Ki-67 in keratocystic odontogenic tumor, Tanta Dental Journal, 10, 3, 2013. Crossref

  17. Cuellar Araceli, Reddi A. Hari, Stimulation of Superficial Zone Protein/Lubricin/PRG4 by Transforming Growth Factor-β in Superficial Zone Articular Chondrocytes and Modulation by Glycosaminoglycans, Tissue Engineering Part A, 21, 13-14, 2015. Crossref

  18. Chen Juan, Wang Yongqian, Chen Chong, Lian Chengjie, Zhou Taifeng, Gao Bo, Wu Zizhao, Xu Caixia, Exogenous Heparan Sulfate Enhances the TGF-β3-Induced Chondrogenesis in Human Mesenchymal Stem Cells by Activating TGF-β/Smad Signaling, Stem Cells International, 2016, 2016. Crossref

  19. Lee Y.-J., Park S.-Y., Lee S.-J., Boo Y.C., Choi J.-Y., Kim J.-E., Ucma, a direct transcriptional target of Runx2 and Osterix, promotes osteoblast differentiation and nodule formation, Osteoarthritis and Cartilage, 23, 8, 2015. Crossref

  20. Bentov Yaakov, Jurisicova Andrea, Kenigsberg Shlomit, Casper Robert F., What maintains the high intra-follicular estradiol concentration in pre-ovulatory follicles?, Journal of Assisted Reproduction and Genetics, 33, 1, 2016. Crossref

  21. Hayes Anthony J., Mitchell Ruth E., Bashford Andrew, Reynolds Scott, Caterson Bruce, Hammond Chrissy L., Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis, Developmental Dynamics, 242, 6, 2013. Crossref

  22. Zhuang Lei, Gerber Simon D., Kuchen Stefan, Villiger Peter M., Trueb Beat, Deletion of exon 8 from the EXT1 gene causes multiple osteochondromas (MO) in a family with three affected members, SpringerPlus, 5, 1, 2016. Crossref

  23. Roach Helmtrud I., Tilley Simon, The Pathogenesis of Osteoarthritis, in Bone and Osteoarthritis, 4, 2007. Crossref

  24. Grieshaber Sarah E., Jha Amit K., Farran Alexandra J. E., Jia Xinqiao, Hydrogels in Tissue Engineering, in Biomaterials for Tissue Engineering Applications, 2011. Crossref

  25. Farran Alexandra J. E., Tong Zhixiang, Witt Robert L., Jia Xinqiao, Tissue Engineering Strategies for Vocal Fold Repair and Regeneration, in Engineering Biomaterials for Regenerative Medicine, 2012. Crossref

  26. Alban S., Kohlenhydrate III: Aminoglykane und Glykosaminoglykane, in Pharmakognosie — Phytopharmazie, 2007. Crossref

  27. Khatri Richa, Schipani Ernestina, About the importance of being desulfated: Figure 1., Genes & Development, 22, 20, 2008. Crossref

  28. Al-Zayed Zayed, Al-Rijjal Roua A., Al-Ghofaili Lamya, BinEssa Huda A., Pant Rajeev, Alrabiah Anwar, Al-Hussainan Thamer, Zou Minjing, Meyer Brian F., Shi Yufei, Mutation spectrum of EXT1 and EXT2 in the Saudi patients with hereditary multiple exostoses, Orphanet Journal of Rare Diseases, 16, 1, 2021. Crossref

  29. Pradhan Swati, Farach-Carson Mary C, Mining the extracellular matrix for tissue engineering applications, Regenerative Medicine, 5, 6, 2010. Crossref

  30. Wang Yaya, Li Lian, Wei Qiang, Chai Rongrong, Yao Qingqiang, Liang Chen, Wang Fuwen, Li Yan, Design, Preparation, and Bioactivity Study of New Fusion Protein HB-NC4 in the Treatment of Osteoarthritis, Frontiers in Bioengineering and Biotechnology, 9, 2021. Crossref

  31. Shu Cindy C., Smith Susan M., Little Christopher B., Melrose James, Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc, Biochemical Journal, 476, 2, 2019. Crossref

  32. Raspopovic J., Marcon L., Russo L., Sharpe J., Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients, Science, 345, 6196, 2014. Crossref

  33. Zuntini M, Pedrini E, Parra A, Sgariglia F, Gentile F V, Pandolfi M, Alberghini M, Sangiorgi L, Genetic models of osteochondroma onset and neoplastic progression: evidence for mechanisms alternative to EXT genes inactivation, Oncogene, 29, 26, 2010. Crossref

  34. Hayes Anthony J., Whitelock John, Melrose James, Regulation of FGF-2, FGF-18 and Transcription Factor Activity by Perlecan in the Maturational Development of Transitional Rudiment and Growth Plate Cartilages and in the Maintenance of Permanent Cartilage Homeostasis, International Journal of Molecular Sciences, 23, 4, 2022. Crossref

  35. Surmann-Schmitt Cordula, Dietz Uwe, Kireva Trayana, Adam Nadia, Park Jung, Tagariello Andreas, Önnerfjord Patrik, Heinegård Dick, Schlötzer-Schrehardt Ursula, Deutzmann Rainer, von der Mark Klaus, Stock Michael, Ucma, a Novel Secreted Cartilage-specific Protein with Implications in Osteogenesis, Journal of Biological Chemistry, 283, 11, 2008. Crossref

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