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Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.841 5-Year IF: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2018025121
pages 373-384

Interferon-Free Regimen for Hepatitis C: Insight and Management

Muhammad Shareef Masoud
Department of Bioinformatics and Biotechnology, Government College University Faisalabad (GCUF), Pakistan
Usman Ali Ashfaq
Department of Bioinformatics & Biotechnology, Government College University, 38000 Faisalabad, Pakistan
Hina Khalid
Department of Bioinformatics and Biotechnology, Government College University Faisalabad (GCUF), Pakistan

ABSTRACT

The rapid development of direct-acting antiviral agents (DAA) for hepatitis C virus (HCV) therapy dramatically altered the treatment landscape of this disease. The DAA regimen is associated with various advantages including high sustained virological response (SVR) with minimum side effects and low pill load and specific inhibition of viral replication, which lowers dependence on the host cell. This regimen has substantially replaced conventional (interferon) therapy with high cure rates (> 90%) in most HCV populations. This review provides insight into clinical studies of NS3/4A protease inhibitors, NS5B viral polymerase inhibitor (nucleotide and non-nucleotide), and NS5A inhibitors, alone and in combination.


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