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Critical Reviews™ in Eukaryotic Gene Expression

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The Unique, Complex Organization of the Transcriptionally Silent Sperm Chromatin

Volume 6, Issue 2-3, 1996, pp. 139-147
DOI: 10.1615/CritRevEukarGeneExpr.v6.i2-3.30
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W. Steven Ward
Division of Urology, Robert Wood Johnson Medical School, New Brunswick, NJ
Andrei O. Zalensky
Department of Biological Chemistry, University of California, Davis, CA

ABSTRACT

The sperm nucleus contains one haploid copy of the genome that is completely transcriptionally silent and is not being replicated. Recent evidence has revealed that this "silent" chromatin nevertheless contains a complex organization at all levels. This includes DNA loop domain formation by the sperm nuclear matrix that is gene specific and highly ordered folding patterns of the chromosomes, particularly with respect to centromere and telomere positioning. Such specificity in the sperm DNA organization suggests functional requirements for their existence. As these begin to emerge, the sperm nucleus is becoming an important model for the study of the eukaryotic genome.

KEY WORDS: sperm chromatin, sperm nucleus, DNA structure
CITED BY

  1. Zalensky Andrei O., Genome architecture, in Genes and Genomes, 5, 1998. Crossref

  2. Agarwal Ashok, Tsarev Igor, Erenpreiss Juris, Sharma Rakesh, Sperm chromatin assessment, in Textbook of Assisted Reproductive Techniques, Volume One: Laboratory Perspectives, 2012. Crossref

  3. Zalenskaya Irina A., Zalensky Andrei O., Telomeres in Mammalian Male Germline Cells, in A Survey of Cell Biology, 218, 2002. Crossref

  4. Erenpreiss J., Spano M., Erenpreisa J., Bungum M., Giwercman A., Sperm chromatin structure and male fertility: biological and clinical aspects, Asian Journal of Andrology, 8, 1, 2006. Crossref

  5. Kozik Alexander, Bradbury E. Morton, Zalensky Andrei, Increased telomere size in sperm cells of mammals with long terminal (TTAGGG)n arrays, Molecular Reproduction and Development, 51, 1, 1998. Crossref

  6. Gurevitch Merav, Amiel Aliza, Ben-Zion Moshe, Fejgin Moshe, Bartoov Benjamin, Acrocentric centromere organization within the chromocenter of the human sperm nucleus, Molecular Reproduction and Development, 60, 4, 2001. Crossref

  7. Meyer-Ficca Mirella L., Lonchar Julia D., Ihara Motomasa, Bader Jessica J., Meyer Ralph G., Alteration of poly(ADP-ribose) metabolism affects murine sperm nuclear architecture by impairing pericentric heterochromatin condensation, Chromosoma, 122, 4, 2013. Crossref

  8. Saperas Núria, Chiva Manel, Casas M. Teresa, Campos J. Lourdes, Eirín-López José M., Frehlick Lindsay J., Prieto Cèlia, Subirana Juan A., Ausió Juan, A unique vertebrate histone H1-related protamine-like protein results in an unusual sperm chromatin organization, FEBS Journal, 273, 19, 2006. Crossref

  9. Hazzouri M., Rousseaux S., Mongelard F., Usson Y., Pelletier R., Faure A.K., Vourc'h C., S�le B., Genome organization in the human sperm nucleus studied by FISH and confocal microscopy, Molecular Reproduction and Development, 55, 3, 2000. Crossref

  10. Hoogendijk Christiaan, Henkel Ralf, The pathophysiology and genetics of human male reproduction, in Male Infertility, 2007. Crossref

  11. Wright Shirley J., , 46, 1999. Crossref

  12. Tai Phillip W.L., Zaidi Sayyed K., Wu Hai, Grandy Rodrigo A., Montecino Martin, van Wijnen André J., Lian Jane B., Stein Gary S., Stein Janet L., The Dynamic Architectural and Epigenetic Nuclear Landscape: Developing the Genomic Almanac of Biology and Disease, Journal of Cellular Physiology, 229, 6, 2014. Crossref

  13. Loi Pasqualino, Fulka Josef, Hildebrand Thomas, Ptak Grazyna, Genome of non-living cells: trash or recycle?, REPRODUCTION, 142, 4, 2011. Crossref

  14. Moskovtsev Sergey I., Willis Jennifer, White John, Mullen J. Brendan M., Disruption of Telomere–Telomere Interactions Associated with DNA Damage in Human Spermatozoa, Systems Biology in Reproductive Medicine, 56, 6, 2010. Crossref

  15. Lewis John D., Song Yue, de Jong Miriam E., Bagha Sabira M., Ausió Juan, A walk though vertebrate and invertebrate protamines, Chromosoma, 111, 8, 2003. Crossref

  16. Carone Benjamin R., Hung Jui-Hung, Hainer Sarah J., Chou Min-Te, Carone Dawn M., Weng Zhiping, Fazzio Thomas G., Rando Oliver J., High-Resolution Mapping of Chromatin Packaging in Mouse Embryonic Stem Cells and Sperm, Developmental Cell, 30, 1, 2014. Crossref

  17. Nanassy Laszlo, Griffin Jeanine, Emery Benjamin R., Carrell Douglas T., The Marmoset and Cotton Rat as Animal Models for the Study of Sperm Chromatin Packaging, Systems Biology in Reproductive Medicine, 56, 3, 2010. Crossref

  18. Njogu Monicah, Ricketts Peta-Gay, Klaus Angela V., Spermatogenic cyst and organ culture in Drosophila pseudoobscura, Cell and Tissue Research, 341, 3, 2010. Crossref

  19. Loi P, Matzukawa K, Ptak G, Natan Y, Fulka Jr J, Arav A, Nuclear Transfer of Freeze-Dried Somatic Cells into Enucleated Sheep Oocytes, Reproduction in Domestic Animals, 43, 2008. Crossref

  20. Zalenskaya Irina A., Bradbury E.Morton, Zalensky Andrei O., Chromatin Structure of Telomere Domain in Human Sperm, Biochemical and Biophysical Research Communications, 279, 1, 2000. Crossref

  21. Gioia Luisa, Barboni Barbara, Turriani Maura, Capacchietti Giulia, Pistilli Maria Gabriella, Berardinelli Paolo, Mattioli Mauro, The capability of reprogramming the male chromatin after fertilization is dependent on the quality of oocyte maturation, Reproduction, 130, 1, 2005. Crossref

  22. Ikeda Shuntaro, Tatemizo Atsuhiro, Iwamoto Daisaku, Taniguchi Shunji, Hoshino Yoichiro, Amano Tomoko, Matsumoto Kazuya, Hosoi Yoshihiko, Iritani Akira, Saeki Kazuhiro, Enhancement of histone acetylation by trichostatin A duringin vitrofertilization of bovine oocytes affects cell number of the inner cell mass of the resulting blastocysts, Zygote, 17, 3, 2009. Crossref

  23. Naz R. K., Effect of Actinomycin D and Cycloheximide on Human Sperm Function, Archives of Andrology, 41, 2, 1998. Crossref

  24. Rousseaux Sophie, Caron Cécile, Pivot-Pajot Christophe, Faure Anne Karen, Hazzouri Mira, Sele Bernard, Khochbin Saadi, Facteurs impliqués dans le remodelage de la chromatine au cours de la spermiogenèse, Andrologie, 13, 2, 2003. Crossref

  25. Drummond R., Does a structural bridge exist between the DNA and the specialized cytoplasmic organelles during the early part of their development? A mechanism for the positioning of flagella and possibly other cytoplasmic organelles, Journal of Theoretical Biology, 223, 3, 2003. Crossref

  26. Rousseaux S., Faure A.-K., Caron C., Lestrat C., Govin J., Hennebicq S., Sèle B., Khochbin S., Organisation nucléaire du spermatozoïde, Gynécologie Obstétrique & Fertilité, 32, 9, 2004. Crossref

  27. Zalensky Andrei O., Tomilin Nikolai V., Zalenskaya Irina A., Teplitz Raymond L., Bradbury E.Morton, Telomere–Telomere Interactions and Candidate Telomere Binding Protein(s) in Mammalian Sperm Cells, Experimental Cell Research, 232, 1, 1997. Crossref

  28. Redgrove Kate A., Anderson Amanda L., Dun Matthew D., McLaughlin Eileen A., O'Bryan Moira K., Aitken R. John, Nixon Brett, Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae, Developmental Biology, 356, 2, 2011. Crossref

  29. Bekaert Sofie, Derradji Hanane, Baatout Sarah, Telomere biology in mammalian germ cells and during development, Developmental Biology, 274, 1, 2004. Crossref

  30. Wong Alexander, Chuan Sandra S., Patton William C., Jacobson John D., Corselli Johannah, Chan Philip J., Addition of eosin to the aniline blue assay to enhance detection of immature sperm histones, Fertility and Sterility, 90, 5, 2008. Crossref

  31. DeJong Jeff, Basic mechanisms for the control of germ cell gene expression, Gene, 366, 1, 2006. Crossref

  32. El-Domyati Moetaz M., Al-Din Abo-Bakr M., Barakat Manal T., El-Fakahany Hasan M., Xu Jiasen, Sakkas Denny, Deoxyribonucleic acid repair and apoptosis in testicular germ cells of aging fertile men: the role of the poly(adenosine diphosphate-ribosyl)ation pathway, Fertility and Sterility, 91, 5, 2009. Crossref

  33. Rousseaux S, Reynoird N, Escoffier E, Thevenon J, Caron C, Khochbin S, Epigenetic reprogramming of the male genome during gametogenesis and in the zygote, Reproductive BioMedicine Online, 16, 4, 2008. Crossref

  34. Martins C.F., Báo S.N., Dode M.N., Correa G.A., Rumpf R., Effects of freeze-drying on cytology, ultrastructure, DNA fragmentation, and fertilizing ability of bovine sperm, Theriogenology, 67, 8, 2007. Crossref

  35. Chauvigné François, Boj Mónica, Finn Roderick Nigel, Cerdà Joan, Mitochondrial aquaporin-8-mediated hydrogen peroxide transport is essential for teleost spermatozoon motility, Scientific Reports, 5, 1, 2015. Crossref

  36. Singh Narendra P, Muller Charles H, Berger Richard E, Effects of age on DNA double-strand breaks and apoptosis in human sperm, Fertility and Sterility, 80, 6, 2003. Crossref

  37. Rousseaux Sophie, Caron Cécile, Govin Jérôme, Lestrat Cécile, Faure Anne-Karen, Khochbin Saadi, Establishment of male-specific epigenetic information, Gene, 345, 2, 2005. Crossref

  38. Rousseaux S., Faure A.-K., Thévenon J., Escoffier E., Lestrat C., Govin J., Hennebicq S., Sèle B., Caron C., Khochbin S., Épigénétique du spermatozoïde, Gynécologie Obstétrique & Fertilité, 34, 9, 2006. Crossref

  39. EVENSON DONALD P., LARSON KJERSTEN L., JOST LORNA K., Sperm Chromatin Structure Assay: Its Clinical Use for Detecting Sperm DNA Fragmentation in Male Infertility and Comparisons With Other Techniques, Journal of Andrology, 23, 1, 2002. Crossref

  40. Li Chun-jin, Wang Dong, Zhou Xu, Sperm proteome and reproductive technologies in mammals, Animal Reproduction Science, 173, 2016. Crossref

  41. Simon L., Aston K. I., Emery B. R., Hotaling J., Carrell D. T., Sperm DNA damage output parameters measured by the alkaline Comet assay and their importance, Andrologia, 49, 2, 2017. Crossref

  42. Gineitis Arunas A., Zalenskaya Irina A., Yau Peter M., Bradbury E. Morton, Zalensky Andrei O., Human Sperm Telomere–Binding Complex Involves Histone H2b and Secures Telomere Membrane Attachment, Journal of Cell Biology, 151, 7, 2000. Crossref

  43. Ahmed Emad, Scherthan Harry, de Rooij Dirk, DNA Double Strand Break Response and Limited Repair Capacity in Mouse Elongated Spermatids, International Journal of Molecular Sciences, 16, 12, 2015. Crossref

  44. Cariati Federica, Jaroudi Souraya, Alfarawati Samer, Raberi Araz, Alviggi Carlo, Pivonello Rosario, Wells Dagan, Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality, Reproductive BioMedicine Online, 33, 3, 2016. Crossref

  45. Zeng Fang, Li Zicong, Cai Gengyuan, Gao Wenchao, Jiang Gelong, Liu Dewu, Urschitz Johann, Moisyadi Stefan, Wu Zhenfang, Characterization of Growth and Reproduction Performance, Transgene Integration, Expression, and Transmission Patterns in Transgenic Pigs Produced by piggyBac Transposition-Mediated Gene Transfer, Animal Biotechnology, 27, 4, 2016. Crossref

  46. Loi Pasqualino, Matsukawa Kazutsugu, Ptak Grazyna, Clinton Michael, Fulka Josef, Nathan Yehudith, Arav Amir, Rutherford Suzannah, Freeze-Dried Somatic Cells Direct Embryonic Development after Nuclear Transfer, PLoS ONE, 3, 8, 2008. Crossref

  47. Shahba Mohamed I., El-Sheshtawy Reda I., El-Azab Abdel-Salam I., Abdel-Ghaffar Alaa E., Ziada Maha S., Zaky Adel A., The effect of freeze-drying media and storage temperature on ultrastructure and DNA of freeze-dried buffalo bull spermatozoa, Asian Pacific Journal of Reproduction, 5, 6, 2016. Crossref

  48. Loi Pasqualino, Clinton Michael, Barboni Barbara, Fulka Josef, Cappai Pietro, Feil Robert, Moor Robert M., Ptak Grazyna, Nuclei of Nonviable Ovine Somatic Cells Develop into Lambs after Nuclear Transplantation, Biology of Reproduction, 67, 1, 2002. Crossref

  49. Meyer Ralph G, Ketchum Chelsea C, Meyer-Ficca Mirella L, Heritable sperm chromatin epigenetics: a break to remember†, Biology of Reproduction, 97, 6, 2017. Crossref

  50. Kozik Alexander, Bradbury E. Morton, Zalensky Andrei O., Identification and Characterization of a Bovine Sperm Protein That Binds Specifically to Single-Stranded Telomeric Deoxyribonucleic Acid1, Biology of Reproduction, 62, 2, 2000. Crossref

  51. Mudrak Olga S., B. Nazarov Igor, Jones Estella L., Zalensky Andrei O., Stanyon Roscoe, Positioning of Chromosomes in Human Spermatozoa Is Determined by Ordered Centromere Arrangement, PLoS ONE, 7, 12, 2012. Crossref

  52. Erenpreiss Juris, Zubkova Ksenija, Cytochemical Tests of Sperm Chromatin Maturity, in A Clinician's Guide to Sperm DNA and Chromatin Damage, 2018. Crossref

  53. Braun Robert E., Packaging paternal chromosomes with protamine, Nature Genetics, 28, 1, 2001. Crossref

  54. Simon Luke, Carrell Douglas T., Zini Armand, Sperm DNA Tests Are Clinically Useful: Pro, in A Clinician's Guide to Sperm DNA and Chromatin Damage, 2018. Crossref

  55. Tumbar Tudorita, Belmont Andrew S., Interphase movements of a DNA chromosome region modulated by VP16 transcriptional activator, Nature Cell Biology, 3, 2, 2001. Crossref

  56. Abdelhedi Fatma, Chalas Céline, Petit Jean-Maurice, Abid Nouha, Mokadem Elyes, Hizem Syrine, Kamoun Hassen, Keskes Leila, Dupont Jean-Michel, Altered three-dimensional organization of sperm genome in DPY19L2-deficient globozoospermic patients, Journal of Assisted Reproduction and Genetics, 36, 1, 2019. Crossref

  57. Meizel Stanley, The sperm, a neuron with a tail: ‘neuronal’ receptors in mammalian sperm, Biological Reviews, 79, 4, 2004. Crossref

  58. Tsarev Igor, Erenpreiss Juris, Cytochemical Tests for Sperm Chromatin Maturity, in Sperm Chromatin for the Researcher, 2013. Crossref

  59. Giwercman Aleksander, Spanò Marcello, Bungum Mona, Sperm DNA Damage: Causes and Guidelines for Current Clinical Practice, in Biennial Review of Infertility, 2011. Crossref

  60. Moskovtsev Sergey I., Mullen Brendan M., The Clinical Utility of the Evaluation of Sperm Chromatin, in Reproductive Endocrinology and Infertility, 2010. Crossref

  61. Meyer-Ficca Mirella L., Meyer Ralph G., Epigenetic changes in the mammalian paternal germ line, in Transgenerational Epigenetics, 2019. Crossref

  62. Tsarev Igor, Erenpreiss Juris, Cytochemical Tests for Sperm Chromatin Maturity, in Sperm Chromatin, 2011. Crossref

  63. Manicardi Gian Carlo, Bizzaro Davide, Sakkas Denny, Basic and Clinical Aspects of Sperm Chromomycin A3 Assay, in Sperm Chromatin, 2011. Crossref

  64. Ausió Juan, Brewer Laurence R., Frehlick Lindsay, Genome Organization by Vertebrate Sperm Nuclear Basic Proteins (SNBPs), in Epigenetics and Human Reproduction, 2011. Crossref

  65. Manicardi Gian Carlo, Bizzaro Davide, Sakkas Denny, Basic and Clinical Aspects of Sperm Chromomycin A3 Assay, in Sperm Chromatin for the Researcher, 2013. Crossref

  66. Sharma Rakesh, Martinez Marlon P., Agarwal Ashok, Sperm Chromatin Integrity Tests and Indications, in Male Infertility, 2020. Crossref

  67. Roque Matheus, Bedoschi Giuliano, Esteves Sandro C., Sperm Physiology and Assessment of Spermatogenesis Kinetics In Vivo, in Male Infertility, 2020. Crossref

  68. Gimenez-Bonafé Pepita, Ribes Enric, Sautière Pierre, Gonzalez Angel, Kasinsky Harold, Kouach Mustafa, Sautière Pierre-Eric, Ausió Juan, Chiva Manel, Chromatin condensation, cysteine-rich protamine, and establishment of disulphide interprotamine bonds during spermiogenesis of Eledone cirrhosa (Cephalopoda), European Journal of Cell Biology, 81, 6, 2002. Crossref

  69. Oehninger Sergio, Kruger Thinus F., Sperm morphology and its disorders in the context of infertility, F&S Reviews, 2, 1, 2021. Crossref

  70. Brewer Laurence, Corzett Michele, Balhorn Rod, Condensation of DNA by Spermatid Basic Nuclear Proteins, Journal of Biological Chemistry, 277, 41, 2002. Crossref

  71. Chopra Shruti, Varma Ajit, Jain Seema, Jain Sangeeta, Choudhary Devendra, Correlation between Sperm Dna Fragmentation and Conventional Semen Parameters among Different Age Groups, Biomedical and Pharmacology Journal, 14, 3, 2021. Crossref

  72. Foster Helen A., Abeydeera Lalantha R., Griffin Darren K., Bridger Joanna M., Non-random chromosome positioning in mammalian sperm nuclei, with migration of the sex chromosomes during late spermatogenesis, Journal of Cell Science, 118, 9, 2005. Crossref

  73. Hennig Wolfgang, DNA Packaging in Sperm, in eLS, 2001. Crossref

  74. Arpanahi Ali, Brinkworth Martin, Iles David, Krawetz Stephen A., Paradowska Agnieszka, Platts Adrian E., Saida Myriam, Steger Klaus, Tedder Philip, Miller David, Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences, Genome Research, 19, 8, 2009. Crossref

  75. Brewer Laurence, Corzett Michele, Lau Edmond Y., Balhorn Rod, Dynamics of Protamine 1 Binding to Single DNA Molecules, Journal of Biological Chemistry, 278, 43, 2003. Crossref

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