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Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.734 5-Year IF: 1.848 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v10.i2.20
7 pages

Targeting Regulatory Factors to Intranuclear Replication Sites

Heinrich Leonhardt
Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
Anje Sporbert
Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
M. Cristina Cardoso
Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany

ABSTRACT

Plenty of evidence exists that mammalian nuclei are highly organized. Complex biochemical processes like DNA replication take place at specialized subnuclear sites and proteins directly or indirectly involved are concentrated at these sites. DNA replication is being used as a paradigm to study this functional organization of the nucleus, its underlying principles, and its potential regulatory consequences. In this review we discuss which factors were shown to be localized at nuclear replication sites, how they get there, and what role this might play in the precise, genome-wide regulation and coordination of complex biochemical processes.


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