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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

The Nuclear Matrix: A Target for Heat Shock Effects and a Determinant for Stress Response

Volume 7, Issue 4, 1997, pp. 343-360
DOI: 10.1615/CritRevEukarGeneExpr.v7.i4.30
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ABSTRACT

The nuclear matrix organizes nuclear DNA into operational DNA domains for replication, transcription, and repair. The proteins of the nuclear matrix are among the most thermal labile proteins in the cell, undergoing denaturation at 43°C to 45°C. Heat-shock-induced protein denaturation results in the aggregation of proteins to the nuclear matrix. As many as 100 protein changes have been observed as a result of this aggregation. Protein aggregation with the nuclear matrix is associated with the disruption of nuclear matrix-dependent DNA replication, DNA transcription, hnRNA processing, and DNA repair. Disruptions of these processes lead to cell death. Nuclear matrix protein changes affect these processes by inhibiting DNA supercoiling ability and inhibiting the access to matrix-associated DNA. Heat-shock proteins are believed to bind denatured proteins and either prevent aggregation or render aggregates more readily dissociable. The nuclear matrix appears to be a target for the detrimental effects of heat shock and hsp70 serves to protect against such effects. However, the nuclear matrix may be involved in the pre- and post-heat shock expression of hsp70. We have found a heat-inducible MAR covering the promoter region of murine hsp70.3, implying that changes in matrix association are needed for hsp70 expression. However, the hsp70.1, 70.3, and hsc70t gene family is organized as an active gene with respect to the nuclear matrix. Thus, it may be that heat-inducible genes have a unique matrix-dependent organization. The work presented in this review implies that the nuclear matrix is a target for the lethal effects of heat and is also a determinant in the protective expression of heat-shock genes.

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  2. Zhu Wei-Guo, Roberts Zachary V., Dynlacht Joseph R., Heat-induced modulation of lamin B content in two different cell lines, Journal of Cellular Biochemistry, 75, 4, 1999. Crossref

  3. Edwards M. J., Nazmi N., Mower C., Daniels A., Hsp72 antigen expression in the proliferative compartment of involved psoriatic epidermis, Journal of Cutaneous Pathology, 26, 10, 1999. Crossref

  4. Dynlacht Joseph R., Story Michael D., Zhu Wei-Guo, Danner Jeffrey, Lamin B is a prompt heat shock protein, Journal of Cellular Physiology, 178, 1, 1999. Crossref

  5. El-Tonsy Mohamed Hany, Anbar Tag El-Din, El-Domyati Moetaz, Barakat Manal, Density of viral particles in pre and post Nd:YAG laser hyperthermia therapy and cryotherapy in plantar warts, International Journal of Dermatology, 38, 5, 1999. Crossref

  6. Roti Roti J.L., Gius D., VanderWaal R.P., Xu M., Changes in sub-nuclear structures and functional perturbations: Implications for radiotherapy, Journal of Cellular Biochemistry, 79, S35, 2000. Crossref

  7. Agutter Paul S., Cell mechanics and stress: from molecular details to the ‘universal cell reaction’ and hormesis, BioEssays, 29, 4, 2007. Crossref

  8. Seno Joshua D., Dynlacht Joseph R., Intracellular redistribution and modification of proteins of the Mre11/Rad50/Nbs1 DNA repair complex following irradiation and heat-shock, Journal of Cellular Physiology, 199, 2, 2004. Crossref

  9. Gharibyan Vazganoush, Youssoufian Hagop, Localization of the bloom syndrome helicase to punctate nuclear structures and the nuclear matrix and regulation during the cell cycle: Comparison with the werner's syndrome helicase, Molecular Carcinogenesis, 26, 4, 1999. Crossref

  10. VanderWaal Robert P., Higashikubo Ruuji, Xu Mai, Spitz Douglas R., Wright William D., Roti Roti Joseph L., Cytometric methods to analyze thermal effects, in Cytometry: Part B, 64, 2001. Crossref

  11. Edwards Ryland B., Lu Yan, Rodriguez Edwin, Markel Mark D., Thermometric determination of cartilage matrix temperatures during thermal chondroplasty, Arthroscopy: The Journal of Arthroscopic & Related Surgery, 18, 4, 2002. Crossref

  12. Dynlacht Joseph R., Bittner M. Eric, Bethel Jody A., Beck Brian D., The non-homologous end-joining pathway is not involved in the radiosensitization of mammalian cells by heat shock, Journal of Cellular Physiology, 196, 3, 2003. Crossref

  13. Willsie Julia K., Clegg James S., Small heat shock protein p26 associates with nuclear lamins and HSP70 in nuclei and nuclear matrix fractions from stressed cells, Journal of Cellular Biochemistry, 84, 3, 2002. Crossref

  14. JIN Mei Lin, ZHANG Ping, DING Ming Xiao, YUN Jing Ping, CHEN Pei Fang, CHEN Yeuk Hon, CHEW Yin Qing, Altered expression of nuclear matrix proteins in etoposide induced apoptosis in HL-60 cells, Cell Research, 11, 2, 2001. Crossref

  15. HAYASHI Masanobu, HAMASU Taku, ENDOH Daiji, KAWANA Ai, MATSUMOTO Minako, OKUI Toyo, High Sensitivity of Fibroblast Cell Lines Derived from LEC Rats to Heat Treatment, Journal of Veterinary Medical Science, 66, 10, 2004. Crossref

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  18. Stein Gary S., Mechanogenomic Control of DNA Exposure and Sequestration, The American Journal of Pathology, 166, 4, 2005. Crossref

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  20. Dynlacht Joseph R., Batuello Christopher N., Lopez Jennifer T., Kim Kyung Keun, Turchi John J., Identification of Mre11 as a Target for Heat Radiosensitization, Radiation Research, 176, 3, 2011. Crossref

  21. Daniely Yaron, Borowiec James A., Formation of a Complex between Nucleolin and Replication Protein a after Cell Stress Prevents Initiation of DNA Replication, Journal of Cell Biology, 149, 4, 2000. Crossref

  22. Livingston Christine M., Ifrim Marius F., Cowan Ann E., Weller Sandra K., Nelson Jay A., Virus-Induced Chaperone-Enriched (VICE) Domains Function as Nuclear Protein Quality Control Centers during HSV-1 Infection, PLoS Pathogens, 5, 10, 2009. Crossref

  23. Falloon Elizabeth A., Dynlacht Joseph R., Reversible changes in the nuclear lamina induced by hyperthermia, Journal of Cellular Biochemistry, 86, 3, 2002. Crossref

  24. Kondo Hidehiro, Harano Ryohei, Nakaya Misako, Watabe Shugo, Characterization of goldfish heat shock protein–30 induced upon severe heat shock in cultured cells, Cell Stress & Chaperones, 9, 4, 2004. Crossref

  25. Zhu Wei-Guo, Seno Joshua D., Beck Brian D., Dynlacht Joseph R., Translocation of MRE11 from the Nucleus to the Cytoplasm as a Mechanism of Radiosensitization by Heat1, Radiation Research, 156, 1, 2001. Crossref

  26. Larsson Carey, Ng Cheng E., p21+/+(CDKN1A+/+) and p21–/–(CDKN1A–/–) Human Colorectal Carcinoma Cells Display Equivalent Amounts of Thermal Radiosensitization, Radiation Research, 160, 2, 2003. Crossref

  27. Dynlacht Joseph R., Roberts Zachary V., Earles Marvin, Henthorn Jim, Seno Joshua D., Different Patterns of DNA Fragmentation and Degradation of Nuclear Matrix Proteins during Apoptosis Induced by Radiation, Hyperthermia or Etoposide1, Radiation Research, 154, 5, 2000. Crossref

  28. Mu Ming-Han, Wang Yi-Ning, Huang Yu, Niu Xue-Li, Chen Hong-Duo, Gao Xing-Hua, Qi Rui-Qun, Local hyperthermia cleared multifarious viral warts in a patient with Cushing's syndrome, Dermatologic Therapy, 32, 4, 2019. Crossref

  29. Beck Brian D., Dynlacht Joseph R., Heat-Induced Aggregation of XRCC5 (Ku80) in Nontolerant and Thermotolerant Cells, Radiation Research, 156, 6, 2001. Crossref

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