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Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v11.i1-3.30
12 pages

Polymeric Delivery of Proteins and Plasmid DNA for Tissue Engineering and Gene Therapy

Thomas P. Richardson
Departments of 1Biomedical Engineering, and Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109
William L. Murphy
Departments of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109
David J. Mooney
Departments of Biomedical Engineering, Chemical Engineering, and Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109

ABSTRACT

In vivo gene expression can be altered by locally delivered DNA and proteins. The ability to deliver bioactive macromolecules, such as proteins and plasmid DNA, over controllable time frames represents a challenging engineering problem. Considerable success has been achieved with polymeric delivery systems that provide the capability to change cell function either acutely or chronically. This review focuses on controlled delivery of proteins and plasmid DNA from polymers and on the effects of controlled delivery on gene expression, and introduces some cell biological and biochemical parameters to be considered when delivering macromolecules to change cell behavior.


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