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Critical Reviews™ in Eukaryotic Gene Expression

Impact factor: 2.385

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v18.i2.60
pages 173-188

Sex Differences in Muscle-Derived Stem Cells and Skeletal Muscle

Bridget M. Deasy
Department of Orthopaedic Surgery, School of Medicine, Department of Bioengineering, School of Engineering, University of Pittsburgh, Pittsburgh, PA 15260; Stem Cell Research Center, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213
Rebecca C. Schugar
Stem Cell Research Center, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213
Johnny Huard
Departments of Orthopaedic Surgery and Molecular Genetics and Biochemistry, Children’s Hospital of Pittsburgh, University of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213-2583

ABSTRACT

Sex is well known to influence life expectancy and disposition to disease. Stem and progenitor cells are believed to persist throughout life, and they contribute to the repair and healthy maintenance of tissue; consequently, sex-related differences demonstrated by stem cells may provide insight to sex-related differences in aging, disease, and healing. However, cell sex is an often overlooked variable in stem cell biology.