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Critical Reviews™ in Eukaryotic Gene Expression

Impact factor: 1.660

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v20.i4.50
pages 341-357

Functional Roles of Osteoactivin in Normal and Disease Processes

Maneet Singh
Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
Fabiola Del Carpio-Cano
Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
Joyce Y. Belcher
Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
Kevin Crawford
Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
Nagat Frara
Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
Thomas A. Owen
Department of Theoretical and Applied Science, Ramapo College of New Jersey, Mahwah, New Jersey; and Department of Cardiovascular and Metabolic Diseases , Pfizer Global Research and Development - Groton Laboratories, Groton, CT 06340, USA
Steven N. Popoff
Department of Anatomy and Cell Biology, and Department of Orthopaedic Surgery and Sport Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
Fayez F. Safadi
Department of Anatomy and Cell Biology, Department of Orthopaedic Surgery and Sport Medicine, Department of Otolaryngology, Temple University School of Medicine, Philadelphia, PA, USA

ABSTRACT

Osteoactivin (OA) protein was discovered in bone cells a decade ago. Recent literature suggests that osteoactivin is crucial for the differentiation and functioning of different cell types, including bone-forming osteoblasts and bone-resorbing osteoclast cells. Here, we review the literature to date on various regulatory functions of osteoactivin, as well as its discovery, structure, expression, and function in different tissues and cells. The transcriptional regulation of osteoactivin and its mechanism of action in normal and diseased conditions with special emphasis on bone are also covered in this review. In addition, we touch on the therapeutic potential of osteoactivin in cancer and bone diseases.