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Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.841 5-Year IF: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v10.i1.40
10 pages

Specialized Transcription Factories within Mammalian Nuclei

Ana Pombo
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, 0X1 3RE, U.K.
Emma Jones
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, 0X1 3RE, U.K.
Francisco J. Iborra
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, 0X1 3RE, U.K.
Hiroshi Kimura
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, 0X1 3RE, U.K.
Kimihiko Sugaya
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, 0X1 3RE, U.K.
Peter R. Cook
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, 0X1 3RE, U.K.
Dean A. Jackson
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, 0X1 3RE, U.K.

ABSTRACT

Recent evidence suggests that active RNA polymerases are concentrated in discrete 'factories' where they work together on many different templates. The evidence that such factories specialize in the transcription of particular groups of genes is reviewed.


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